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Understanding the pathways that are aberrantly regulated might also open new avenues for therapeutic interventions with novel targeted therapeutics.

Understanding the pathways that are aberrantly regulated might also open new avenues for therapeutic interventions with novel targeted therapeutics.

aberrantly

akzessorisch

DNA hypomethylation of aberrantly methylated genes involved in normal cell cycle regulation, differentiation and death pathways may result in gene re-expression and restoration of cancer- suppressing functions to cancer cells.

Die DNA-Hypomethylierung von irrtümlich methylierten Genen, die an der normalen Regulation des Zellzyklus, der Zelldifferenzierung und den Apoptose-Pathways beteiligt sind, könnte in Krebszellen zur Re-expression der Gene und zur Wiederherstellung krebsunterdrückender Funktionen führen.

Keratin, a main component of intermediate filaments of KCs, has been found to be aberrantly expressed in psoriasis. In normal skin, basal cells express two keratins, K5 and K14, whereas suprabasal cells express differentiation-related keratins K1 and K10 (Fig. 1A). In psoriasis, the changes in keratin expression include a reduction in K1 and K10 and the induction of hyperproliferation-associated keratins K6, K16 and K17 (Fig. 1B)

Keratin, ein Hauptbestandteil der Intermediärfilamente von KCs, wurde festgestellt, dass bei Psoriasis aberrant exprimiert werden. In der normalen Haut, ausdrücken Basalzellen zwei Keratine, K5 und K14, während Suprabasalzellen-bezogene Differenzierung zum Ausdruck bringen Keratine K1 und K10 (Abb. 1A). In Psoriasis, die Änderungen in Keratin Ausdruck eine Reduzierung der K1 und K10 und die Induktion von Hyperproliferation-assoziierten Keratine K6, K16 und K17 (Abb. 1B)

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