antiproliferative

Hence, the study concluded that curcumin induces apoptosis via a ROS-associated mechanism that converges on JNK activation, and to a lesser extent via a parallel ceramide-associated pathway (153). Curcumin reduced the hydrolytic capacity of the cells against choline-labeled sphingomyelin, associated with a mild increase in cellular sphingomyelin in the cells. Curcumin also inhibited acid sphingomyelinase an effect that may account for its antiproliferative effects against colon cancer cells (152).

Daher schloss die Studie, dass, dass Curcumin Apoptosis über einen Mechanismus ROS-assoziierten induziert, die über die Aktivierung von JNK und in geringerem Maße über eine parallele Ceramid-assoziierte Weg (153) konvergiert. Curcumin reduziert die hydrolytische Kapazität der Zellen gegen Cholin-beschrifteten Sphingomyelin, verbunden mit einem milden Anstieg der zellulären Sphingomyelin in den Zellen. Curcumin unterdrückt auch saure Sphingomyelinase ein Effekt, der für seine Antiproliferative Wirkung gegen Krebszellen "Doppelpunkt" (152) berücksichtigen kann.

A771726, the active metabolite of leflunomide, inhibits the human enzyme dihydroorotate dehydrogenase (DHODH) and exhibits antiproliferative activity.

A771726, der aktive Metabolit von Leflunomid, hemmt beim Menschen das Enzym Dihydroorotatdehydrogenase (DHODH) und zeigt eine antiproliferative Wirkung.

Leflunomide is a disease-modifying anti-rheumatic agent with antiproliferative properties.

Leflunomid ist ein antirheumatisches Basistherapeutikum (,,disease modifying antirheumatic drug " (DMARD)) mit antiproliferativen Eigenschaften.

It has immunomodulating/immunosuppressive characteristics, acts as an antiproliferative agent, and displays anti-inflammatory properties.

Es besitzt immunmodulatorische/immunsuppressive Merkmale, wirkt antiproliferativ und zeigt antiphlogistische Eigenschaften.

The Nrf2/antioxidant response element (ARE) signaling pathway plays a key role in activating cellular antioxidants, including heme oxygenase-1 (HO-1), NADPH quinone oxidoreductase-1 (NQO1), and glutathione. Curcumin treatment results in ROS generation, activation of Nrf2 and MAP kinases and the inhibition of phosphatase activity in hepatocytes, and when curcumin is not administered in toxic doses, these multiple pathways converge to induce HO-1 (253). Another study further suggests that curcumin has the ability to induce HO-1 expression, presumably through Nrf2-dependent ARE activation in rat vascular smooth muscle cells and human aortic smooth muscle cells, and provide evidence that the antiproliferative effect of curcumin is considerably linked to its ability to induce HO-1 expression

Das Nrf2/Antioxidant Response-Element (sind) Signalisierung Signalweg spielt eine Schlüsselrolle bei der Aktivierung von zellulärer Antioxidantien, einschließlich Häm-Oxygenase-1 (HO-1), NADPH-Chinon-Oxidoreduktase-1 (NQO1) und Glutathion. Curcumin Behandlungsergebnisse in ROS-Generation, Aktivierung von Nrf2 und MAP-Kinasen und die Hemmung der Phosphatase-Aktivität in Hepatozyten und wenn Curcumin nicht toxische Dosen, diese mehrere Wege verabreicht wird konvergieren um HO-1 (253) induzieren. Eine andere Studie weiter suggeriert, dass Curcumin hat die Fähigkeit, HO-1 Ausdruck zu induzieren, vermutlich durch Nrf2-abhängigen sind Aktivierung in Ratte vaskulären glatten Muskelzellen und menschlichen Aortenklappe glatten Muskelzellen und belegen, dass die Antiproliferative Wirkung von Curcumin erheblich an dessen Fähigkeit, HO-1 Ausdruck induzieren verknüpft ist

FBAL is a metabolite without antiproliferative activity.

FBAL ist ein Metabolit ohne antiproliferative Aktivität.

Hemocompatible medical product according to any one of the preceding claims, characterized in that the at least one antiproliferative, anti-inflammatory, antiphlogistic and/or antithrombotic agent is selected from the group comprising: sirolimus (rapamycin), everolimus, somatostatin, tacrolimus, roxithromycin, daunamycin, ascomycin, bafilomycin, erythromycin, midecamycin, josamycin, concanamycin, clarithromycin, troleandomycin, folimycin, cerivastatin, simvastatin, lovastatin, fluvastatin, rosuvastatin, atorvastatin, pravastatin, pitavastatin, vinblastine, vincristine, vindesine, vinorelbine, etoposide, teniposide, nimustine, carmustine, lomustine, cyclophosphamide, C-type natriuretic peptide (CNP), 4-hydroxycyclophosphamide, estramustine, melphalan, ifosfamide, trofosfamide, chlorambucil, bendamustine, dacarbazine, busulfan, procarbazine, treosulfan, temozolomide, thiotepa, daunorubicin, doxorubicin, aclarubicin, epirubicin, idarubicin, bleomycin, mitomycin, dactinomycin, methotrexate, fludarabine, fludarabine-5'-dihydrogen phosphate, cladribine, mercaptopurine, thioguanine, cytarabine, fluorouracil, gemcitabine, capecitabine, docetaxel, carboplatin, cisplatin, cryptophycins, anginex, oxaliplatin, amsacrine, irinotecan, topotecan, hydroxycarbamide, miltefosine, pentostatin, aldesleukin, tretinoin, asparaginase, pegaspargase, anastrozole, exemestane, letrozole, formestane, aminoglutethimide, adriamycin, azithromycin, spiramycin, cepharanthin, inhibitor 2? of smc proliferation, epothilone A and B, mitoxantrone, azathioprine, mycophenolate mofetil, c-myc antisense, b-myc antisense, betulinic acid, camptothecin, lapachol, ?-lapachone, podophyllotoxin, betulin, podophyllic acid 2-ethylhydrazide, molgramostim (rhuGM-CSF), peginterferon ?-2b, lenograstim (r-HuG-CSF), filgrastim, macrogol, basiliximab, daclizumab, selectin (cytokine antagonist), CETP inhibitor, cadherins, cytokinin inhibitors, COX-2 inhibitor, AE-941 (Neovastat ® ), NFkB, angiopeptin, ciprofloxacin, fluroblastin, monoclonal antibodies inhibiting muscle cell proliferation, bFGF antagonists, probucol, prostaglandins, Ac-YVAD-CMK, 1,11-dimethoxycanthin-6-one, 1-hydroxy-11-methoxycanthin-6-one, scopoletin, colchicine, NO donors such as pentaerythritol tetranitrate and sydnonimines, S-nitroso derivatives, tamoxifen, staurosporine, ?-estradiol, ?-estradiol, estriol, estrone, ethinyl estradiol, fosfestrol, medroxyprogesterone, estradiol cypionates, estradiol benzoates, tranilast, kamebakaurin and other terpenoids used for the therapy of cancer, verapamil, tyrosine kinase inhibitors (tyrphostins), cyclosporine A, paclitaxel and derivatives thereof such as 6-?-hydroxy-paclitaxel, baccatin, taxoteres and other macrocyclic oligomers of carbon suboxide (MCS) obtained synthetically and from native sources and derivatives thereof, mofebutazone, acemetacin, diclofenac, lonazolac, dapsone, o-carbamoyl-phenoxy-acetic acid, lidocaine, ketoprofen, mefenamic acid, piroxicam, meloxicam, chloroquine phosphate, penicillamine, hydroxychloroquine, auranofin, sodium aurothiomalate, oxaceprol, celecoxib, ?-sitosterol, ademetionine, myrtecaine, polidocanol, nonivamide, levomenthol, benzocaine, aescin, ellipticine, D-24851 (Calbiochem), colcemid, cytochalasin A-E, indanocine, nocodazole, protein S 100, bacitracin, vitronectin receptor antagonists, azelastine, guanidyl cyclase stimulator, tissue inhibitor of metal proteinases 1 and 2, free nucleic acids, nucleic acids incorporated into virus transmitters, DNA and RNA fragments, plasminogen activator inhibitor 1, plasminogen activator inhibitor 2, antisense oligonucleotides, VEGF inhibitors, IGF-1, active ingredients from the group of antibiotics such as cefadroxil, cefazolin, cefaclor, cefoxitin, tobramycin, gentamicin, penicillins such as dicloxacillin, oxacillin, sulfonamides, metronidazole, antithrombotics such as argatroban, aspirin, abciximab, synthetic antithrombin, bivalirudin, coumadin, enoxaparin, desulfated and N-reacetylated heparin (Hemoparin ® ), tissue plasminogen activator, Gpllb/llla platelet membrane receptor, factor Xa-inhibitor antibody, heparin, hirudin, r-hirudin, PPACK, protamine, prourokinase, streptokinase, warfarin, urokinase, vasodilators such as dipyramidole, triazolopyrimidine (Trapidil ® ), nitroprussides, PDGF antagonists such as triazolopyrimidine and seramin, ACE inhibitors such as captopril, cilazapril, lisinopril, enalapril, losartan, thioprotease inhibitors, prostacyclin, vapiprost, interferon ?, ? and ?, histamine antagonists, serotonin blockers, apoptosis inhibitors, apoptosis regulators such as p65, NF-kB or Bcl-xL antisense oligonucleotides, halofuginone, nifedipine, tocopherol, molsidomine, tea polyphenols, epicatechin gallate, epigallocatechin gallate, boswellic acids and derivatives thereof, leflunomide, anakinra, etanercept, sulfasalazine, tetracycline, triamcinolone, mutamycin, procainimide, retinoic acid, quinidine, disopyramide, flecainide, propafenone, sotalol, amidarone, natural and synthetically obtained steroids such as bryophyllin A, inotodiol, maquiroside A, ghalakinoside, mansonine, strebloside, hydrocortisone, betamethasone, dexamethasone, non-steroidal substances (NSAIDS) such as fenoprofen, ibuprofen, indomethacin, naproxen, phenylbutazone and other antiviral agents such as acyclovir, ganciclovir and zidovudine, antimycotics such as clotrimazole, flucytosine, griseofulvin, ketoconazole, miconazole, nystatin, terbinafine, antiprotozoal agents such as chloroquine, mefloquine, quinine, furthermore natural terpenoids such as hippocaesculin, barringtogenol-C21-angelat, 14-dehydroagrostistachin, agroskerin, agrostistachin, 17-hydroxyagrostistachin, ovatodiolides, 4,7-oxycycloanisomelic acid baccharinoids B1, B2, B3 and B7, tubeimoside, bruceanols A, B and C, bruceantinoside C, yadanzioside N and P, isodeoxyelephantopin, tomenphantopin A and B, coronarin A, B, C and D, ursolic acid, hyptatic acid A, zeorin, iso-iridogermanal, maytenfoliol, effusantin A, excisanin A and B, longikaurin B, sculponeatin C, kamebaunin, leukamenin A and B, 13,18-dehydro-6-alpha-senecioyloxychaparrin, taxamairin A and B, regenilol, triptolide, furthermore cymarin, apocymarin, aristolochic acid, anopterin, hydroxyanopterin, anemonin, protoanemonin, cheliburin chloride, cicutoxin, sinococuline, combrestratin A and B, cudraisoflavone A, curcumin, dihydronitidine, nitidine chloride, 12-?-hydroxypregnadien-3,20-dione, bilobol, ginkgol, ginkgolic acid, helenalin, indicine, indicine-N-oxide, lasiocarpine, glycoside 1a, justicidin A and B, larreatin, malloterin, mallotochromanol, isobutyryl-mallotochromanol, marchantin A, maytansine, lycoridicin, margetin, pancratistatin, aristolactam-All, bisparthenolidine, periplocoside A, deoxypsorospermin, psycorubin, ricin A, sanguinarine, manwu wheat acid, methylsorbifolin, chromones from spathelia, stizophyllin, akagerine, dihydro-usambarensine, hydroxy-usambarine, strychnopentamine, strychnophylline, usambarine, usambarensine, berberine, liriodenine, oxoushinsunine, daphnoretin, lariciresinol, methoxylariciresinol, syringaresinol, umbelliferone, afromoson, acetylvismione B, desacetylvismione A, vismione A and B. Hemocompatible medical product according to claim 8, characterized in that the at least one antiproliferative, anti-inflammatory, antiphlogistic and/or antithrombotic agent is selected from the group comprising: paclitaxel and derivatives thereof, ?-estradiol, simvastatin, Pl 88 (Progen Ind.), macrocyclic carbon suboxides (MCS) and derivatives thereof, trapidil ® , N-(pyridin-4-yl)-[1-4-(4-chlorobenzyl)-indol-3-yl]-glyoxyl amid (D-24851), activated protein C (aPC), Ac-YVAD-CMK, anginex (?-Pep25), Neovastat ® , cryptophycin 52, tacrolimus.

Hemokompatibles Medizinprodukt nach einem der vorherigen Ansprüche, dadurch gekennzeichnet, dass der mindestens eine antiproliferative, antiinflammatorische, antiphlogistische und/oder antithrombotische Wirkstoffe aus der Gruppe ausgewählt wird umfassend: Sirolimus (Rapamycin), Everolimus, Somatostatin, Tacrolimus, Roxithromycin, Dunaimycin, Ascomycin, Bafilomycin, Erythromycin, Midecamycin, Josamycin, Concanamycin, Clarithromycin, Troleandomycin, Folimycin, Cerivastatin, Simvastatin, Lovastatin, Fluvastatin, Rosuvastatin, Atorvastatin, Pravastatin, Pitavastatin, Vinblastin, Vincristin, Vindesin, Vinorelbin, Etobosid, Teniposid, Nimustin, Carmustin, Lomustin, Cyclophosphamid, C-Type Natriuretic Peptide (CNP), 4-Hydroxycyclophosphamid, Estramustin, Melphalan, Ifosfamid, Tropfosfamid, Chlorambucil, Bendamustin, Dacarbazin, Busulfan, Procarbazin, Treosulfan, Tremozolomid, Thiotepa, Daunorubicin, Doxorubicin, Aclarubicin, Epirubicin, Mitoxantron, Idarubicin, Bleomycin, Mitomycin, Dactinomycin, Methotrexat, Fludarabin, Fludarabin-5'-dihydrogenphosphat, Cladribin, Mercaptopurin, Thioguanin, Cytarabin, Fluorouracil, Gemcitabin, Capecitabin, Docetaxel, Carboplatin, Cisplatin, Cryptophycine, Anginex, Oxaliplatin, Amsacrin, Irinotecan, Topotecan, Hydroxycarbamid, Miltefosin, Pentostatin, Aldesleukin, Tretinoin, Asparaginase, Pegasparase, Anastrozol, Exemestan, Letrozol, Formestan, Aminoglutethemid, Adriamycin, Azithromycin, Spiramycin, Cepharantin, SMC-Proliferation-Inhibitor-2w, Epothilone A und B, Mitoxanthrone, Azathioprin, Mycophenolatmofetil, c-myc-Antisense, b-myc-Antisense, Betulinsäure, Camptothecin, Lapachol, ?-Lapachon,Podophyllotoxin, Betulin, Podophyllsäure-2-ethylhydrazid, Molgramostim (rhuGM-CSF), Peginterferon ?-2b, Lanograstim (r-HuG-CSF), Filgrastim, Macrogol, Anginex, Na-Uretic-Peptide, Dacarbazin, Basiliximab, Daclizumab, Selectin (Cytokinantagonist), Chryptophycine, CETP-Inhibitor, Cadherine, Cytokininhibitoren, COX-2-Inhibitor, AE-941 (Neovastat®), NFkB, Angiopeptin, Ciprofloxacin, Camptothecin, Fluroblastin, monoklonale Antikörper, die die Muskelzellproliferation hemmen, bFGF-Antagonisten, Probucol, Prostaglandine, Ac-YVAD-CMK, 1,11-Dimethoxycanthin-6-on, 1-Hydroxy-11-Methoxycanthin-6-on, Scopolectin, Colchicin, NO-Donoren wie Pentaerythrityltetranitrat und Syndnoeimine, S-Nitrosoderivate, Tamoxifen, Staurosporin, ?-Estradiol, ?-Estradiol, Estriol, Estron, Ethinylestradiol, Fosfestrol, Medroxyprogesteron, Estradiolcypionate, Estradiolbenzoate, Tranilast, Kamebakaurin und andere Terpenoide, die in der Krebstherapie eingesetzt werden, Verapamil, Tyrosin-Kinase-Inhibitoren (Tyrphostine), Cyclosporin A, Paclitaxel und dessen Derivate wie 6-?-Hydroxy-Paclitaxel, Baccatin, Taxotere u.a., synthetisch hergestellte als auch aus nativen Quellen gewonnene macrocyclische Oligomere des Kohlensuboxids (MCS) und seine Derivate, Mofebutazon, Acemetacin, Diclofenac, Lonazolac, Dapson, o-Carbamoylphenoxyessigsäure, Lidocain, Ketoprofen, Mefenaminsäure, Piroxicam, Meloxicam, Chloroquinphosphat, Penicillamin, Hydroxychloroquin, Auranofin, Natriumaurothiomalat, Oxaceprol, Celecoxib, ?-Sitosterin, Ademetionin, Myrtecain, Polidocanol, Nonivamid, Levomenthol, Benzocain, Aescin, Ellipticin, D-24851 (Calbiochem), Colcemid, Cytochalasin A-E, Indanocine, Nocadazole, S 100 Protein, Bacitracin, Vitronectin-Rezeptor Antagonisten, Azelastin, Guanidylcyclase-Stimulator Gewebsinhibitor der Metallproteinase-1 und 2, freie Nukleinsäuren, Nukleinsäuren in Virenüberträger inkorporiert, DNA- und RNA-Fragmente, Plaminogen-Aktivator Inhibitor-1, Plasminogen-Aktivator Inhibitor-2, Antisense Oligonucleotide, VEGF-Inhibitoren, IGF-1, Wirkstoffe aus der Gruppe der Antibiotika wie Cefadroxil, Cefazolin, Cefaclor, Cefotixin Tobramycin, Gentamycin, Penicilline wie Dicloxacillin, Oxacillin, Sulfonamide, Metronidazol, Antithrombotika wie Argatroban, Aspirin, Abciximab, synthetisches Antithrombin, Bivalirudin, Coumadin, Enoxoparin, desulfatiertes und N-reacetyliertes Heparin (Hemoparin®), Gewebe-Plasminogen-Aktivator, GpIIb/IIIa-Plättchenmembranrezeptor, Faktor X a -Inhibitor Antikörper, Heparin, Hirudin, r-Hirudin, PPACK, Protamin, Prourokinase, Streptokinase, Warfarin, Urokinase, Vasodilatoren wie Dipyramidol, Triazolopyrimidine (Trapidil®), Nitroprusside, PDGF-Antagonisten wie Triazolopyrimidin und Seramin, ACE-Inhibitoren wie Captopril, Cilazapril, Lisinopril, Enalapril, Losartan, Thioproteaseinhibitoren, Prostacyclin, Vapiprost, Interferon ?, ? und ?, Histaminantagonisten, Serotoninblocker, Apoptoseinhibitoren, Apoptoseregulatoren wie p65, NF-kB oder Bcl-xL-Antisense-Oligonukleotiden, Halofuginon, Nifedipin, Tocopherol Tranilast, Molsidomin, Teepolyphenole, Epicatechingallat, Epigallocatechingallat, Boswellinsäuren und ihre Derivate, Leflunomid, Anakinra, Etanercept, Sulfasalazin, Etoposid, Dicloxacyllin, Tetracyclin, Triamcinolon, Mutamycin, Procainimid, Retinolsäure, Quinidin, Disopyrimid, Flecainid, Propafenon, Sotolol, Amidoron., natürliche und synthetisch hergestellte Steroide wie Bryophyllin A, Inotodiol, Maquirosid A, Ghalakinosid, Mansonin, Streblosid, Hydrocortison, Betamethason, Dexamethason, nichtsteroidale Substanzen (NSAIDS) wie Fenoporfen, Ibuprofen, Indomethacin, Naproxen, Phenylbutazon und andere antivirale Agentien wie Acyclovir, Ganciclovir und Zidovudin, Antimykotika wie Clotrimazol, Flucytosin, Griseofulvin, Ketoconazol, Miconazol, Nystatin, Terbinafin, antiprozoale Agentien wie Chloroquin, Mefloquin, Quinin, des weiteren natürliche Terpenoide wie Hippocaesculin, Barringtogenol-C21-angelat, 14-Dehydroagrostistachin, Agroskerin, Agrostistachin, 17-Hydroxyagrostistachin, Ovatodiolide, 4,7-Oxycycloanisomelsäure, Baccharinoide B1, B2, B3 und B7, Tubeimosid, Bruceanole A,B und C, Bruceantinoside C, Yadanzioside N, und P, Isodeoxyelephantopin, Tomenphantopin A und B, Coronarin A,B,C und D, Ursolsäure, Hyptatsäure A, Zeorin, Iso-Iridogermanal. Maytenfoliol, Effusantin A, Excisanin A und B, Longikaurin B, Sculponeatin C, Kamebaunin, Leukamenin A und B, 13,18-Dehydro-6-alpha-Senecioyloxychaparrin, Taxamairin A und B, Regenilol, Triptolid, des weiteren Cymarin, Apocymarin, Aristolochsäure, Anopterin, Hydroxyanopterin, Anemonin, Protoanemonin, Berberin, Cheliburinchlorid, Cictoxin, Sinococulin, Bombrestatin A und B, Cudraisoflavon A, Curcumin, Dihydronitidin, Nitidinchlorid, 12-beta-Hydroxypregnadien 3,20-dion, Bilobol, Ginkgol, Ginkgolsäure, Helenalin, Indicin, Indicin-N-oxid, Lasiocarpin, Inotodiol, Glykosid 1a, Podophyllotoxin, Justicidin A und B, Larreatin, Malloterin, Mallotochromanol, Isobutyrylmallotochromanol, Maquirosid A, Marchantin A, Maytansin, Lycoridicin, Margetin, Pancratistatin, Liriodenin, Bispsrthenolidin, Oxoushinsunin, Aristolactam-All, Bisparthenolidin, Periplocosid A, Ghalakinosid, Ursolsäure, Deoxypsorospermin, Psycorubin, Ricin A, Sanguinarin, Manwuweizsäure, Methylsorbifolin, Sphatheliachromen, Stizophyllin, Mansonin, Streblosid, Akagerin, Dihydrousambaraensin, Hydroxyusambarin, Strychnopentamin, Strychnophyllin, Usambarin, Usambarensin, Berberin, Liriodenin, Oxoushinsunin, Daphnoretin, Lariciresinol, Methoxylariciresinol, Syringaresinol, Umbelliferon, Afromoson, Acetylvismion B, Desacetylvismion A, Vismion A und B umfassen. Hemokompatibles Medizinprodukt nach Anspruch 8, dadurch gekennzeichnet, dass der mindestens eine antiproliferative, antiinflammatorische, antiphlogistische und/oder antithrombotische Wirkstoffe aus der Gruppe ausgewählt wird umfassend: Paclitaxel und seine Derivate, ?-Estradiol, Simvastatin, PI 88 (Progen Ind.), Macrocyclische Kohlensuboxide (MCS) und deren Derivate, Trapidil ® , N-(Pyridin-4-yl)-[1-4-(4-chlorobenzyl)-indol-3-yl]-glyoxylamid (D-24851), aktiviertes Protein C (aPC), Ac-YVAD-CMK, Anginex (?-Pep25), Neovastat ® , Cryptophycin 52, Tacrolimus handelt.

Therapeutic Classes These pharmaceutically active substances may belong to one or more active ingredient classes such as ACE inhibitors, adrenergics, adrenocorticosteroids, acne therapeutic agents, aldose reductase inhibitors, aldosterone antagonists, alpha-glucosidase inhibitors, alpha 1 antagonists, remedies for alcohol abuse, amino acids, amoebicides, anabolics, analeptics, anaesthetic additions, anaesthetics (non-inhalational), anaesthetics (local), analgesics, androgens, angina therapeutic agents, antagonists, antiallergics, antiallergics such as PDE inhibitors, antiallergics for asthma treatment, further antiallergics (e.g. leukotriene antagonists, antianaemics, antiandrogens, antianxiolytics, antiarthritics, antiarrhythmics, antiatheriosclerotics, antibiotics, anticholinergics, anticonvulsants, antidepressants, antidiabetics, antidiarrhoeals, antidiuretics, antidotes, antiemetics, antiepileptics, antifibrinolytics, antiepileptics, antihelmintics, antihistamines, antihypotensives, antihypertensives, antihypertensives, antihypotensives, anticoagulants, antimycotics, antiestrogens, antiestrogens (non-steroidal), antiparkinson agents, antiinflammatory agents, antiproliferative active ingredients, antiprotozoal active ingredients, antirheumatics, antischistosomicides, antispasmolytics, antithrombotics, antitussives, appetite suppressants, arteriosclerosis remedies, bacteriostatics, beta-blockers, beta-receptor blockers, bronchodilators, carbonic anhydrase inhibitors, chemotherapeutic agents, choleretics, cholinergics, cholinergic agonists, cholinesterase inhibitors, agents for the treatment of ulcerative colitis, cyclooxygenaze inhibitors diuretics, ectoparasiticides, emetics, enzymes, enzyme inhibitors, enzyme inhibitors, active ingredients to counter vomiting, fibrinolytics, fungistatics, gout remedies, glaucoma therapeutic agents, glucocorticoids, glucocorticosteroids, haemostatics, cardiac glycosides, histamine H2 antagonists, hormones and their inhibitors, immunotherapeutic agents, cardiotonics, coccidiostats, laxatives, lipid-lowering agents, gastrointestinal therapeutic agents, malaria therapeutic agents, migraine remedies, microbiocides, Crohn's disease, metastasis inhibitors, migraine remedies, mineral preparations, motility-increasing active ingredients, muscle relaxants, neuroleptics, active ingredients for treatment of estrogens, osteoporosis, otologicals, antiparkinson agents, phytopharmaceuticals, proton pump inhibitors, prostaglandins, active ingredients for treating benign prostate hyperblasia, active ingredients for treating pruritus, psoriasis active ingredients, psychoactive drugs, free-radical scavengers, renin antagonists, thyroid therapeutic agents, active ingredients for treating seborrhoea, active ingredients to counter seasickness, spasmolytics, alpha- and beta-sympathomimetics, tenatoprazole, platelet aggregation inhibitors, tranquilizers, ulcer therapeutic agents, further ulcer therapeutic agents, agents for the treatment of urolithiasis, virustatics, vitamins, cytokines, active ingredients for combination therapy with cytostatics, cytostatics.

Diese pharmazeutisch aktiven Substanzen können einer oder mehrerer Wirkstoffklassen angehören, wie ACE-Hemmer, Adrenergika, Adrenocortikosteroide, Aknetherapeutika, Aldose-Reduktase-Hemmer, Aldosteron-Antagonisten, Alpha-Glucosidasehemmer, Alpha 1- Antagonisten, Mittel gegen Alkoholabusus, Aminosäuren, Amöbizide, Anabolika, Analeptika, Anaesthetika-Zusätze, Anaesthetika (nicht inhalativ), Anaesthetika (lokal), Analgetika, Androgene, Anginatherapeutika, Antagonisten, Antiallergika, Antiallergika wie PDE-Hemmer, Antiallergika zur Asthmabehandlung, Weitere Antiallergika (z.B. Leukotrienantagonisten, Antianämika, Antiandrogene, Antianxiolytika, Antiarthritika, Antiarrhythmika, Antiatheriosklerotika, Antibiotika, Anticholinergika, Anticonvulsiva, Antidepressiva, Antidiabetika, Antidiarrhoika, Antidiuretika, Antidots, Antiemetika, Antiepileptika, Antifibrinolytika, Antiepileptika, Antihelmintika, Antihistaminika, Antihypotensiva, Antihypertensiva, Antihypertonika, Antihypotonika, Antikoagulantien, Antimykotika, Antiöstrogene, Antiöstrogene (Nicht-Steroide), Antiparkinson-Mittel, Antiphlogistika, Antiproliferative Wirkstoffe, Antiprotozoen Wirkstoffe, Antirheumatika, Antischistosomizide, Antispasmolytika, Antithrombotika, Antitussiva, Appetitzügler, Arteriosklerosemittel, Bakteriostatika, Betablocker, Betarezeptorenblocker, Bronchodilatoren, Carboanhydrase-Hemmer, Chemotherapeutika, Choleretika, Cholinergika, Cholinergische Agonisten, Cholinesterase-Hemmer, Mittel zur Behandlung von Colitis ulcerosa, Cyclooxigenasehemmer, Diuretika, Ektoparasitizide, Emetika, Enzyme, Enzym-Hemmer, Enzyminhibitoren, Wirkstoffe gegen Erbrechen, Fibrinolytika, Fungistatika, Gichtmittel, Glaukomtherapeutika, Glucocorticoide, Glucocortikosteroide, Hämostatika, Herzglykoside, Histamin H2-Antagonisten, Hormone und deren Hemmstoffe, Immuntherapeutika, Kardiotonika, Kokkidiostatika, Laxantien, Lipidsenker, Magen-Darmtherapeutika, Malariatherapeutika, Migränemittel, Mikrobiozide, Morbus Crohn, Metastasenhemmer, Migränemittel, Mineralstoffpräparate, motilitätssteigernde Wirkstoffe, Muskelrelaxantien, Neuroleptika, Wirkstoffe zur Behandlung der Oestrogene, Osteoporose, Otologika, Parkinsonmittel, Phytopharmaka, Protonenpumpenhemmer, Prostaglandine, Wirkstoffe zur Behandlung der benignen Prostatahyperblasie, Wirkstoffe zur Behandlung des Pruritus, Psoriasis Wirkstoffe, Psychopharmaka, Radikalfänger, Renin-Antagonisten, Schilddrüsentherapeutika, Wirkstoffe zur Behandlung von Seborrhoe, Wirkstoffe gegen Seekrankheit, Spasmolytika, alpha- und beta-Sympatomimetika, Tenatoprazol, Thrombozytenaggregationshemmer, Tyrosinkinaseinhibitoren, Tranquilizer, Ulkustherapeutika, Weitere Ulkustherapeutika, Mittel zur Behandlung der Urolithiasis, Virustatika, Vitamine, Zytokine, Wirkstoffe für die Kombinationstherapie mit Zytostatika, Zytostatika.