Chinolin

Verfahren gemäß Anspruch 7 oder 8, worin der Extraktionsbeschleuniger ausgewählt ist aus der Gruppe bestehend aus Pyridin, Methylpyridin, Ethylpyridin, Chinolin und Tryptophan.

The method according to claim 7 or 8, wherein the extraction accelerator is selected from the group consisting of pyridine, methylpyridine, ethylpyridine, quinoline, and tryptophan.

Verbindung von Anspruch 12, wobei der Extraktionsbeschleuniger ausgewählt ist aus der Gruppe bestehend aus Pyridin, Methylpyridin, Ethylpyridin, Chinolin, Tryptophan und Phenylalanin.

A composition of claim 12, wherein the extraction accelerator is selected from the group consisting of pyridine, methylpyridine, ethylpyridine, quinoline, tryptophan and phenylalanine.

Pharmazeutische Zusammensetzung nach Anspruch 1, die eine therapeutisch wirksame Menge einer Verbindung umfasst, ausgewählt aus der Gruppe bestehend aus: N 1 -[4-(4-Amino-1H-imidazo[4,5-c]chinolin-1-yl)butyl]benzamid; N 1 -[4-(4-Amino-2-propyl-1H-imidazo[4,5-c]chinolin-1-yl)butyl]benzamid; N 1 -[4-(4-Amino-2-methyl-1H-imidazo[4,5-c]chinolin-1-yl)butyl]benzamid; N 1 -[4-(4-Amino-2-ethyl-1H-imidazo[4,5-c]chinolin-1-yl)butyl]benzamid; N 1 -[4-(4-Amino-2-butyl-1H-imidazo[4,5-c]chinolin-1-yl)butyl]benzamid; N 1 -[5-(4-Amino-2-methyl-1H-imidazo[4,5-c]chinolin-1-yl)pentyl]benzamid; N 1 -[5-(4-Amino-1H-imidazo[4,5-c]chinolin-1-yl)pentyl]benzamid; N 1 -[3-(4-Amino-1H-imidazo[4,5-c]chinolin-1-yl)propyl]benzamid; N 1 -[2-(4-Amino-1H-imidazo[4,5-c]chinolin-1-yl)ethyl]benzamid; N 1 -[3-(4-Amino-2-methyl-1H-imidazo[4,5-c]chinolin-1-yl)propyl]benzamid; N 1 -[6-(4-Amino-1H-imidazo[4,5-c]chinolin-1-yl)hexyl]benzamid; N 1 -[4-(4-Amino-1H-imidazo[4,5-c]chinolin-1-yl)butyl]-3-phenylpropanamid; N 1 -[2-(4-Amino-1H-imidazo[4,5-c]chinolin-1-yl)ethyl]-3-phenylpropanamid; N 1 -[4-(4-Amino-1H-imidazo[4,5-c]chinolin-1-yl)butyl]-2-phenoxyacetamid; N 1 -[4-(4-Amino-1H-imidazo[4,5-c]chinolin-1-yl)butyl]-2-ethylhexanamid; N 1 -[4-(4-Amino-1H-imidazo[4,5-c]chinolin-1-yl)butyl]-2-phenoxypropanamid; N 1 -[4-(4-Amino-1H-imidazo[4,5-c]chinolin-1-yl)butyl]-2-chlorobenzamid; N 1 -[4-(4-Amino-1H-imidazo[4,5-c]chinolin-1-yl)butyl]-3,4-dichlorbenzamid; N 1 -[4-(4-Amino-1H-imidazo[4,5-c]chinolin-1-yl)butyl]-2,6-dichlorbenzamid; N 1 -[4-(4-Amino-1H-imidazo[4,5-c]chinolin-1-yl)butyl]-4-fluorbenzamid; N 1 -[4-(4-Amino-1H-imidazo[4,5-c]chinolin-1-yl)butyl]-4-chlorbenzamid; N 1 -[4-(4-Amino-1H-imidazo[4,5-c]chinolin-1-yl)butyl]-4-methoxybenzamid; N 1 -[4-(4-Amino-1H-imidazo[4,5-c]chinolin-1-yl)butyl]-4-(trifluoromethyl)benzamid; N 1 -[4-(4-Amino-1H-imidazo[4,5-c]chinolin-1-yl)butyl]-2-phenylacetamid; N 1 -[4-(4-Amino-1H-imidazo[4,5-c]chinolin-1-yl)butyl]-(E)-3-phenyl-2-propenamid; N 1 -[4-(4-Amino-1H-imidazo[4,5-c]chinolin-1-yl)butyl]-3-cyclopentylpropanamid; N 1 -[4-(4-Amino-1H-imidazo[4,5-c]chiriolin-1-yl)butyl]-1-cyclopentancarboxamid; N 1 -[4-(4-Amino-1H-imidazo[4,5-c]chinolin-1-yl)butyl]-1-cyclohexancarboxamid; N 1 -{4-[4-Amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]chinolin-1-yl]butyl}-2-methylbenzamid; N 1 -{4-[4-Amino-2-(2-methoxyethyl)-1H-imidazo [4,5-c]chinolin-1-yl]butyl}-1-cyclopentancarboxamid; N 1 -{4-[4-Amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]chinolin-1-yl]butyl}-1-cyclohexancarboxamid, N 1 -{4-(4-Amino-2-(2-methoxyethyl)-6,7,8,9-tetrahydro-1H-imidazo[4,5-c]chinolin-1-yl]butyl}benzamid; N 1 -{4-[4-Amino-2-(2-methoxyethyl)-6,7,8,9-tetrahydro-1H-imidazo[4,5-c]chinolin-1-yl]butyl}-2-phenylacetamid; N 1 -[4-(4-Amino-2-(4-methoxybenzyl)-1H-imidazo[4,5-c]chinolin-1-yl)butyl]acetamid; N 1 -[4-(4-Amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]chinolin-1-yl)butyl]acetamid; N 1 -[4-(4-Amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]chinolin-1-yl)butyl]-2,2,2-trifluoracetamid; N 1 -[4-(4-Amino-1H-imidazo[4,5-c]chinolin-1-yl)butyl]-2,2,2-trifluoracetamid; N 1 -[4-(4-Amino-1H-imidazo[4,5-c]chinolin-1-yl)butyl]-(trans)-2-phenylcyclopropan-1-carboxamid; und N 1 -{4-[4-Amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]chinolin-1-yl]butyl}-(trans)-2-phenylcyclopropan-1-carboxamid in Kombination mit einem pharmazeutisch verträglichen Träger.

A pharmaceutical composition according to claim 1 comprising a therapeutically effective amount of a compound selected from the group consisting of: N 1 -[4-(4=Amino-1 H -imidazo[4;5- c ]quinolin-1yl)butyl]benzamide N 1 -[4-(4-Amino-2-propyl-1 H -imidazo[4,5- c ]quinolin-1-yl)butyl]benzamide N 1 -[4-(4-Amino-2-methyl-1 H -imidazo[4,5- c ]quinolin-1-yl)butyl]benzamide; N 1 -[4-(4-Amino-2-ethyl-1 H -imidazo[4,5- c ]quinolin-1-yl)butyl]benzamide N 1 -[4-(4-Amino-2-butyl-1 H -imidazo[4;5- c ]quinolin-1-yl)butyl]benzamide; N 1 -[5-(4-Amino-2-methyl-1 H -imidazo[4,5- c ]quinolin-1-yl)pentyl]benzamide; N 1 -[5-(4-Amino-1 H -imidazo[4,5- c ]qinolin-1-yl)pentyl]benzamide; N 1 -[3-(4-Amino-1 H -imidazo[4,5- c ]quinolin-1-yl)propyl]benzamide; N 1 -[2-(4-Amino-1 H -imidazo[4,5- c ]quinolin-1-yl)ethyl]benzamide; N 1 -[3-(4-Amino-2-methyl-1 H -imidazo[4,5- c ]quinolin-1-yl)propyl]benzamide; N 1 -[6-(4-Amino-1 H -imidazo[4,5- c ]quinolin-1-yl)hexyl]benzamide; N 1 -[4-(4-Amino-1 H -imidazo[4,5- c ]quinolin-1-yl)butyl]-3-phenylpropanamide; N 1 -[2-(4-Amino-1 H -imidazo[4,5- c ]quinolin-1-yl)ethyl]-3-phenylpropanamide; N 1 -[4-(4-Amino-1 H -imidazo[4,5- c ]quinolin-1-yl)butyl]-2-phenoxyacetamide; N 1 -[4-(4-Amino-1 H -imidazo[4,5- c ]quinolin-1-yl)butyl]-2-ethylexanamide; N 1 -[4-(4-Amino-1 H -imidazo[4,5- c ]quinolin-1-yl)butyl]-2-phenoxypropanamide; N 1 -[4-(4-Amino-1 H -imidazo[4,5- c ]quinolin-1-yl)butyl]-2-chlorobenzamide; N 1 -[4-(4-Amino-1 H -imidazo[4,5- c ]quinolin-1-yl)butyl]-3,4-dichlorobenzamide; N 1 -[4-(4-Amino-1 H -imidazo[4,5- c ]quinolin-1-yl)butyl]-2,6-dichlorobenzamide; N 1 -[4-(4-Amino-1 H -imidazo[4,5- c ]quinolin-1-yl)butyl]-4-fluorobenzamide; N 1 -[4-(4-Amino-1 H -imidazo[4,5- c ]quinolin-1-yl)butyl]-4-chlorobenzamide; N 1 -[4-(4-Amino-1 H -imidazo[4,5- c ]quinolin-1-yl)butyl]-4-methoxybenzamide; N 1 -[4-(4-Amino-1 H -imidazo[4,5- c ]quinolin-1-yl)butyl]-4-(trifluoromethyl)benzamide; N 1 -[4-(4-Amino-1 H -imidazo[4,5- c ]quinolin-1-yl)butyl]-2-phenylacetamide; N 1 -[4-(4-Amino-1 H -imidazo[4,5- c ]quinolin-1-yl)butyl]-(E)-3-phenyl-2 propenamide; N 1 -[4-(4-Amino-1 H -imidazo[4,5- c ]quinolin-1-yl)butyl]-3-cyclopentylpropanemide; N 1 -[4-(4-Amino-1 H -imidazol[4,5- c ]quinolin-1-yl)buyl]-1-cyclopentanecarboxamide; N 1 -[4-(4-Amino-1 H -imidazo[4,5- c ]quinolin-1-yl)bytyl]-1-cyclohexanecarboxamide N 1 -{4-[4-Amino-2-(2-methoxyethyl)1 H -imidazo[4,5- c ]quinolin-1-yl]butyl)-2-methylbenzamide; N 1 {4-[4-Amino-2-(2-methoxyethyl)-1 H -imidazo[4,5- c ]quinolin-1-yl]butyl)-1-cyclopentanecarboxamide; N 1 -{4-[4-Amino-2-(2-methoxyethyl)-1 H -imidazo[4,5- c ]quinolin-1-yl]butyl}-1-cycohexanecarboxamide, N 1 -{4-[4-Amino-2-(2-methoxyethyl)-6,7,8,9-tetrahydro-1 H -imidazo[4,5-c]quinolin-1-yl]butyl}benzamide; N 1 -{4-[4-Amino-2-(2-methoxyethyl)-6,7,8,9-tetrahydro-1 H -imidazole[4,5- c ]quinolin-1-yl]butyl}-2-phenylacetamide; N 1 -[4-(4-Amino-2-(4-methoxybenzyl)-1 H -imidazo[4,5- c ]quinolin-1-yl)butyl]acetamide; N 1 -[4-(4-Amino-2-(2-methoxyethyl)-1 H -imidazo[4,5- c ]quinolin-1-yl)butyl]acetamide; N 1 -[4-(4-Amino-2-(2-methoxyethyl)-1 H -imidazo[4,5- c ]quinolin-1-yl)butyl]-2,2,2-trifluoroacetamide; N 1 -[4-(4-Amino-1 H -imidazo[4,5- c ]quinolin-1-yl)butyl]-2,2,2-trifluoroacetamide; N 1 -[4-(4-Amino-1 H -imidazo[4,5- c ]quinolin-1-yl)butyl] ( trans )-2-phenylcyclopropane-1-carboxamide; and N 1 -{4-[4-Amino-2-(2-methoxyethyl)-1 H -imidazo[4,5- c ]quinolin-1-yl]butyl}-( trans )-2-phenylcyclopropane-1-carboxamide; in combination with a pharmaceutically acceptable carrier.

Cyclische Amidverbindung gemäß mindestens einem der Ansprüche 1 bis 4, welche eine der folgenden Verbindungen ist: N-[(S)-1,2-Dioxo-1-N-(2-methyl-2-propyl)amino-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-(phenylmethoxy-carbonylamino)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-(3,4-methylen-dioxyphenylcarbonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-[(4-methoxycarbonyl)piperazin-1-carbonyl]amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-[(4-acetyl)piperazin-1-carbonyl]amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-5-(methylthio)-3-pentyl]-1-[N-[(4-methoxycarbonyl)piperazin-1-carbonyl]amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-5-(methylthio)-3-pentyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-5-methylthio-3-pentyl]-1-[N-(phenylmethoxycarbonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-5-methylthio-3-pentyl]-1-[N-(3,4-methylendioxyphenylcarbonyl)amino]cyclohexancarboxamid; N-[(S)-1-[N-(Cyclopentyl)amino]-1,2-dioxo-5-methylthio-3-pentyl]-1-(N-(phenyloxycarbonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-5-methylthio-3-pentyl]-1-[N-(2-methylpropyloxycarbonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-3-butyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-3-butyl]-1-[N-(3,4-methylen-dioxycarbonyl)amino] cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-4-methyl-3-pentyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-4-methyl-3-pentyl]-1-[N-(3,4-methylendioxyphenylcarbonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-4-methyl-3-pentyl]-1- [N-[(4-methoxycarbonyl)piperazin-1-carbonyl]amino]cyclohexancarboxamid; N-[(S)-1-Amino-1,2-dioxo-4-methyl-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-Amino-1,2-dioxo-3-heptyl)-1-[N-(phenylmetoxycarbonyl)amino]cyclohexancarboxamid; N-[(S)-1-Amino-1,2-dioxo-3-heptyl]-1-[N-(3,4-methylendioxyphenylcarbonyl)amino]cyclohexancarboxamid; N-[(S)-1-Amino-1,2-dioxo-3-heptyl]-1-(phenylsulfonylmethyl)cyclohexancarboxamid; N-[(S)-1-Amino-1,2-dioxo-3-heptyl)-1-[N-[(2-methyl-2-propyloxycarbonyl)piperidin-4-carbonyl]amino]cyclohexancarboxamid; N-[(S)-1-Amino-1,2-dioxo-3-heptyl]-1-[N-[4-(2-methyl-2-propyloxycarbonyl)piperazin-1-carbonyl]amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-methoxy-3-heptyl]-1-(N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-Oxo-1-carboxy-2-hexyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(3-pyrazolyl)amino-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-Amino-1,2-dioxo-3-heptyl]-1-[N-piperazin-1-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-[N-(3-Chlorphenylmethyl)amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino] cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(3-fluorphenylmethyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(3-nitrophenylmethyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Methylamino)-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-2-Propylamino)-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclohexylamino)-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino] cyclohexancarboxamid; N-[(S)-1-(N-Phenylamino)-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Morpholin-4-amino)-1,2-dioxo-3-heptyl]-1-(N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(3-methoxyphenylmethyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(2-thiazolyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(phenylmethyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(tetrahydro-2-furylmethyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(2-oxotetrahydro-3-furyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino] cyclohexancarboxamid; N-[(S)-1-[N-(Cyclopentylmethyl)amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-[N-(1-Methylcyclopentyl)amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(1-indanyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino] cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(2-indanyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-[N-(Cyclobutyl)amino]-1,2-dioxo-3-heptyl]-1-(N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(3-pyridyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino] cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(furylmethyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N,N-Dimethylamino)-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(1-methylcyclopentylmethyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-(phenylsulfonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-5-methyl-3-hexyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-5-methyl-3-hexyl]-1-[N-[(4-methoxycarbonyl)piperazin-1-carbonyl]amino)cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-(4-methoxybenzolsulfonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-(4-nitrobenzol-sulfonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-4-methyl-3-pentyl]-1-[N-[(4-acetyl)piperazin-1-carbonyl]amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylmethylamino)-1,2-dioxo-5-methyl-3-hexyl]-1-[N-(4-acetylpiperazin-1-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-(chinolin-8-sulfonyl)amino]cyclohexancarboxamid; N-((S)-1-(N-Cyclopentylamino)-1,2-dioxo-S-methyl-3-hexyl)-1-[N-[(4-acetyl)piperazin-1-carbonyl]amino]cyclohexanearboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-sulfonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-5-methyl-3-hexyl]-1-[N-(morpholin-4-sulfonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-(4-acetylpiperazin-1-sulfonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-5-methyl-3-hexyl]-1-[N-(4-acetylpiperazin-1-sulfonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-4-methyl-3-pentyl]-1-[N-(4-acetylpiperazin-1-sulfonyl)amino]cyclohexancarboxamid; N-[(S)-1-[N-(2,2-Dimethylpropyl)amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-(pyridin-3-sulfonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylmethylamino)-1,2-dioxo-3-heptyl]-1-[N-(4-acetyl-piperazin-1-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-(4-acetylamino-benzol-1-sulfonyl)amino] cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(1-hydroxycyclohexylmethyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-[(4-ethoxycarbonyl)piperazin-1-carbonyl]amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-[(4-methylsulfonyl)piperazin-1-carbonyl]amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-[(4-isobutyryl)piperazin-1-carbonyl]ammo]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-(thiamorpholin-4-carbonyl)amino]cyclohexancarboxamid; [(S)-1-(N-Cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-[(4-ethoxycarbonyl)piperidin-1-earbonyl]amino]cyclohexanearboxamid; N-[(S)-1,2-Dioxo-1-[N-(2-oxo-2-phenylethyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-[(2-methyl-1,3-benzodioxolan-2-yl)methyl]amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-[(2-phenyl-1,3-dioxolan-2-yl)methyl] amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-[N-(2,2-Dimethoxyethyl)amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-[(1,3-dioxolan-2-yl)methyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-[N-[(2-Methyl-1,3-dioxolan-2-yl)methyl]amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-N-[(S)-(1-phenylethyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-N-[(R)-(1-phenylethyl)amino]-3-heptyl]-1- [N-(morpholin-4-carbonyl)amino] cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-3-pentylamino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(2-methylphenyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-[(4-acetyl)perhydro-4-azaazepin-1-carbonyl]amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-[(4-methoxy)piperidin-1-carbonyl]amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-[N,N-bis(2-methoxyethyl)aminocarbonyl]amino]cyclohexancarboxamid; N-[(S)-1-(N-Cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-[[N-(2-methoxyethyl)-N-methyl]aminocarbonyl]amino]cyclohexancarboxamid; N-((S)-1,2-Dioxo-1-[N-[(S)-1-oxo-1-methoxy-3-methyl-2-butyl]amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-[N-[(3,4-Dihydro-2H-pyran-6-yl)methyl] amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-[N-[(2-Cyclohexyl-2-oxo)ethyl]amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(1-methoxycyclohexylmethyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-[(RS)-2-oxocyclohexyl] amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino] cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-N-[[(RS)-4-methyl-1-oxo-1-[N-(phenylmethyl)amino]-2-pentyl]amino]-3-pentyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-N-[(RS)-1-phenylsulfonyl-5-methylthio-1-penten-3-yl]amino-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-N-[[(RS)-4-methyl-1-oxo-1-(phenylmethyl)oxy-2-pentyl)amino]-3-pentyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-[N-[(2-Methyl-1,3-dioxan-2-yl)methyl)amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-[N-[[2-(1,1-Dimethylethyl)-1,3-dioxolan-2-yl]methyl]amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1 -[N-[(2,5,5-Trimethyl-1,3-dioxan-2-yl)methyl]amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino)cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(4-phenoxyphenyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(1-benzoyl-piperidin-4-yl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(4-oxo-1-cyclohexyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1 -[N-(3,3-Dimethyl-2-oxobutyl)amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-[2-(phenylsulfonyl)ethyl]amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(2-oxo-3-phenylpropyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(2-oxo-4-phenylbutyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(2-methyl-2-phenoxypropyl)amino]-3-heptyl)-1-[N-(morpholin-4-carbonyl)amino] cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-[(R)-2-oxocyclohexyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-((S)-1,2-Dioxo-1-[N-[(S)-2-oxocyclohexyl]amino]-3-heptyl)-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-[(1RS)-2-oxo-1-cyclohexyl]amino]-5-methyl-3-hexyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-[(S)-3-methyl-1-oxo-1-(phenylmethoxy)-2-butyl]amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-[(R)-1-methoxy-3-methyl-1-oxo-2-butyl]amino]-3-heptyl]-1 - [N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-[(R)-2-methoxy-2-oxo-1-phenylethyl]amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-[(R)-2-oxocyclopentyl]amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-[(S)-2-oxocyclopentyl]amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-[(S)-3-methyl-1-oxo-1-[N-(phenylmethyl)amino]-2-butyl]amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-[(S)-3-methyl-1-oxo-1-[N-(1,1-dimethylethyl)amino]-2-butyl]amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-[4-(ethoxycarbonylmethylen)cyclohexan-1-yl]amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(1,4-dioxaspiro[4,5]decan-8-yl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-[N-[(S)-Hexahydro-2-azepinon-3-yl] amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; [(S)-1,2-Dioxo-1-[N-[(25,3S)-1-methoxy-3-methyl-1-oxo-2-hexyl]amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-[(S)-2-methoxy-2-oxo-1-phenylethyl]amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-[(S)-3,3-dimethyl-1-methoxy-1-oxo-2-butyl]amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-[N-[(S)-3-Methyl-1-oxo-1-phenyl-2-butyl]amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino] cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-[[(2-(2-propyl)-1,3-dioxolan-2-yl] methyl]amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-[N-[(S)-4-Methyl-2-oxo-3-pentyl]amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino] cyclohexancarboxamid; N-[(S)-1-[N-[(S)-2-Methyl-1-(2-methyl-1,3-dioxolan-2-yl)propyl]amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino] cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(4-methoxyphenyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-[N-(4-Fluorphenyl)amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1-[N-(3,5-Difluorphenyl)amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid N-[(S)-1,2-Dioxo-1-[N-[(S)-2-methyl-1-oxo-1-(N-phenylamino)-2-butyl]amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(3,4-methylendioxyphenylmethyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-[(S)-1-methylamino-2-methyl-1-oxo-2-butyl]amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(3S)-1,2-Dioxo-1-[N-[(1RS)-1-methoxy-3-methyl-2-butyl]amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(3S)-1,2-Dioxo-1-[N-[(1RS)-1-phenoxy-3-methyl-2-butyl] amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(3,4-methylendioxyphenyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(2-benzothiazolyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino] cyclohexancarboxamid; N-[(3S)-1,2-Dioxo-1-[N-[(1S)-1-oxo-1-methoxy-3-phenyl-2-propyl]amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(3S)-1,2-Dioxo-1-[N-[(R)-1-oxo-1-methoxy-3-methylthio-2-propyl]amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(3S)-1,2-Dioxo-1-[N-[(S)-1,4-dioxo-1,4-dimethoxy-2-butyl] amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-[2-(3,4-methylendioxyphenyl)ethyl]amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-(3,4-dimethoxyphenyl)amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid; N-[(S)-1,2-Dioxo-1-[N-[2-(3,4-dimethoxyphenyl)ethyl]amino]-3-heptyl]-1-[N-(morpholin-4-carbonyl)amino]cyclohexancarboxamid.

A cyclic amide compound according to any of claims 1 to 4 which is one of the following compounds: N-[(S)-1,2-dioxo-1-N-(2-methyl-2-propyl)amino-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-(phenylmethoxy-carbonylamino)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-(3,4-methylene-dioxyphenylcarbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-[(4-methoxycarbonyl) piperazine-1-carbonyl]amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-[(4-acetyl)piperazine-1-carbonyl]amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-5-(methylthio)-3-pentyl]-1-[N-[(4-methoxycarbonyl)piperazine-1-carbonyl]amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-5-(methylthio)-3-pentyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-5-methylthio-3-pentyl]-1-[N-(phenylmethoxycarbo-nyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-5-methylthio-3-pentyl]-1-[N-(3, 4-methylenedioxyphenylcarbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-[N-(cyclopentyl)amino]-1,2-dioxo-5-methylthio-3-pentyl]-1-(N-(phenyloxycarbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-5-methylthio-3-pentyl]-1-[N-(2-methylpropyloxycarbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1, 2-dioxo-3-butyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-3-butyl]-1-[N-(3,4-methylene-dioxycarbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-4-methyl-3-pentyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-4-methyl-3-pentyl]-1-[N-(3,4-methylenedioxyphenylcarbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-4-methyl-3-pentyl]-1-[N-[(4-methoxycarbonyl)piperazine-1-carbonyl]amino]cyclohexanecarboxamide; N-[(S)-1-amino-1,2-dioxo-4-methyl-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-amino-1,2-dioxo-3-heptyl]-1-[N-(phenylmetoxycarbonyl)amino] cyclohexanecarboxamide; N-[(S)-1-amino-1,2-dioxo-3-heptyl]-1-[N-(3,4-methylendioxyphenylcarbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-amino-1,2-dioxo-3-heptyl]-1-(phenylsulfonylmethyl) cyclohexanecarboxamide; N-[(S)-1-amino-1,2-dioxo-3-heptyl]-1-[N-[(2-methyt-2-propyloxycarbonyl) piperidine-4-carbonyl]amino]cyclohexanecarboxamide; N-[S)-1-amino-1,2-dioxo-3-heptyl]-1-[N-[4-(2-methyl-2-propyloxycarbonyl) piperazine-1-carbonyl]amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-methoxy-3-heptyl]-1-(N-(morpholine-4-carbonyl)amino] cyclohexanecarboxamide; N-[(S)-1-oxo-1-carboxy-2-hexyl]-1-[N-(morpholine-4-carbonyl)amino] Cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(3-pyrazolyl)amino-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-amino-1,2-dioxo-3-heptyl]-1-[N-piperazine-1-carbonyl) amino]cyclohexanecarboxamide; N-[(S)-1-[N-(3-chlorophenylmethyl) amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(3-fluorophenylmethyl) amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(3-nitrophenylmethyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-methylamino)-1,2-dioxo-3-heptyl]-1-[N-(morpholine -4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-2-propylamino)-1,2-dioxo-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclohexylamino)-1,2-dioxo-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-phenylamino)-1,2-dioxo-3-heptyl]-1-[N-(morpholine-4 carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-morpholine-4-amino)-1,2-dioxo-3-heptyl]-1-(N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(3-methoxyphenylmethyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(2-thiazolyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(phenylmethyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(tetrahydro-2-furylmethyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(2-oxotetrahydro-3-furyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-[N-(cyclopentylmethyl)amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-[N-(1-methylcyclopentyl)amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(1-indanyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(2-indanyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-[N-(cyclobutyl)amino]-1,2-dioxo-3-heptyl]-1-(N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(3-pyridyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(furylmethyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N,N-dimethylamino)-1,2-dioxo-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(1-methylcyclopentylmethyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-(phenylsulfonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-5-methyl-3-hexyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-5-methyl-3-hexyl]-1-[N-[(4-methoxy-carbonyl)piperazine-1-carbonyl]amino] cyclohexanecarboxamide; N-[(S)- 1 -(N-cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-(4-methoxybenzenesulfonyl) amino]cyclohex-anecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-(4-nitrobenzenesulfonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-4-methyl-3-pentyl]-1-[N-[(4-acetyl)piperazine-1-carbonyl]amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylmethylamino)-1,2-dioxo-5-methyl-3-hexyl]-1-[N-(4-acetylpiperazine-1-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-(quinoline-8-sulfonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-5-methyl-3-hexyl]-1-[N-[(4-acetyl)piperazine-1-carbonyl]amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-(morpholine-4-sulfonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-5-methyl-3-hexyl]-1-[N-(morpholine-4-sulfonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-(4-acetylpiperazine-1-sulfonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-5-methyl-3-hexyl]-1-[N-(4-acetylpiperazine-1-sulfonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-4-methyl-3-pentyl]-1-[N-(4-acetylpiperazine-1-sulfonyl)amino]cyclohexanecarboxamide; N-[(S)-1-[N-(2,2-dimethylpropyl)amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-(pyridine-3-sulfonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylmethylamino)-1,2-dioxo-3-heptyl]-1-[N-(4-acetyl-piperazine-1-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-(4-acetylamino-benzene-1-sulfonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(1-hydroxycyclohexylmethyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-[(4-ethoxycarbonyl)piperazine-1-carbonyl]amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-[(4-methylsulfonyl)piperazine-1-carbonyl]amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-[(4-isobutyryl) piperazine-1-carbonyl]amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-(thiamorpholine-4-carbonyl)amino]cyclohexanecarboxamide; [(S)-1-(N-cyclopentylamino)- 1,2-dioxo-3-heptyl]-1-[N-[(4-ethoxycarbonyl)piperidine-1-carbonyl]amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(2-oxo-2-phenylethyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-[(2-methyl-1,3-benzodioxolane-2-yl)methyl]amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino] cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-[(2-phenyl-1,3-dioxolane-2-yl)methyl] amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-[N-(2,2-dimethoxyethyl)amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-[(1,3-dioxolane-2-yl)methyl]amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-[N-[(2-methyl-1,3-dioxolane-2-yl)methyl]amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-N-[(S)-(1-phenylethyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-N-[(R)-(1-phenylethyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-3-pentylamino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(2-methylphenyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-[(4-acetyl)perhydro-4-azaazepine-1-carbonyl]amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-[(4-methoxy) piperidine-1-carbonyl]amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-[N,N-bis(2-methoxyethyl)aminocarbonyl]amino]cyclohexanecarboxamide; N-[(S)-1-(N-cyclopentylamino)-1,2-dioxo-3-heptyl]-1-[N-[[N-(2-methoxyethyl)-N-methyl]aminocarbonyl]amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-[(S)-1-oxo-1-methoxy-3-methyl-2-butyl]amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino] cyclohexanecarboxamide; N-[(S)-1-[N-[(3,4-dihydro-2H-pyrane-6-yl)methyl]amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholine-4-carbo-nyl)amino]cyclohexanecarboxamide; N-[(S)-1-[N-[(2-cyclohexyl-2-oxo)ethyl]amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(1-methoxycyclohexylmethyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-[(RS)-2-oxocyclohexyl]amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-N-[[(RS)-4-methyl-1-oxo-1-[N-(phenylmethyl)amino]-2-pentyl]amino]-3-pentyl]-1-[N-(morpholine-4-carbonyl) amino]cyclohexaneccarboxamide; N-[(S)-1,2-dioxo-1-N-[(RS)-1-phenylsulfonyl-5-methylthio-1-pentene-3-yl] amino-3-heptyl]-1-[N-(morphotline-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-N-[[(RS)-4-methyl-1-oxo-1-(phenylmethyl) oxy-2-pentyl]amino]-3-pentyl]-1-[N-(morpholine-4-carbonyl)amino] cyclohexanecarboxamide; N-[(S)-1-[N-[(2-methyl-1,3-dioxane-2-yl)methyl]amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-[N-[[2-(1,1-dimethylethyl)-1,3-dioxolane-2-yl]methyl] amino]-1,2-dioxo-3-heptyl]-1-[N-(morpho-line-4-carbonyl)amino] cyclohexanecarboxamide; N-[(S)-1-[N-[(2,5,5-trimethyl-1,3-dioxane-2-yl)methyl]amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(4-phenoxyphenyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(1-benzoyl-piperidine-4-yl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(4-oxo-1-cyclohexyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-[N-(3,3-dimethyl-2-oxobutyl)amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-[2-(phenylsulfonyl)ethyl]amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(2-oxo-3-phenylpropyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(2-oxo-4-phenylbutyl)amino]-3-heptyl]- 1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(2-methyl-2-phenoxypropyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-[(R)-2-oxocyclohexyl]amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-[(S)-2-oxocyclohexyl]amino]-3-heptyl]-1-[N-(morpholine-4-carbo-nyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-[(1RS)-2-oxo-1-cyclohexyl]amino]-5-methyl-3-hexyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-[(S)-3-methyl-1-oxo-1-(phenylmethoxy)-2-butyl]amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino] cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-[(R)-1-methoxy-3-methyl-1-oxo-2-butyl] amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-[(R)-2-methoxy-2-oxo-1-phenylethyl] amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-[(R)-2-oxocyclopentyl]amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-[(S)-2-oxocyclopentyl]amino]-3-heptyl]-1-[N-(morpholine-4-carbo-nyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-[(S)-3-methyl-1-oxo-1-[N-(phenylmethyl) amino]-2-butyl]amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino] cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-[(S)-3-methyl-1-oxo-1-[N-(1,1-dimethylethyl)amino]-2-butyl]amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl) amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-[4-(ethoxycarbonylmethylene) cyclohexane-1-yl]amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino] cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(1,4-dioxaspiro[4,5]decane-8-yl)amino]-3-heptyl]-1-[N-(morpholine-4-carbo-nyl)amino]cyclohexanecarboxamide; N-[(S)-1-[N-[(S)-hexahydro-2-azepinone-3-yl]amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; [(S)-1,2-dioxo-1-[N-[(2S, 3S)-1-methoxy-3-methyl-1-oxo-2-hexyl]amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-[(S)-2-methoxy-2-oxo-1-phenylethyl] amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-[(S)-3,3-dimethyl-1-methoxy-1-oxo-2-butyl]amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-[N-[(S)-3-methyl-1-oxo-1-phenyl-2-butyl]amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-[[(2-(2-propyl)-1,3-dioxolane-2-yl] methyl]amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-[N-[(S)-4-methyl-2-oxo-3-pentyl]amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholine-4-carbo-nyl)amino]cyclohexanecarboxamide; N-[(S)-1-[N-[(S)-2-methyl-1-(2-methyl-1,3-dioxolane-2-yl) propyl]amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino] cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(4-methoxyphenyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1-[N-(4-fluorophenyl)amino]-1,2-dioxo-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexane-carboxamide; N-[(S)-1-[N-(3,5-difluorophenyl)amino]-1,2-dioxo-3-heptyl]-1-[N-(morphofine-4-carbonyl)amino]cyclohexanecarboxamide N-[(S)-1,2-dioxo-1-[N-[(S)-2-methyl-1-oxo-1-(N-phenylamino)-2-butyl]amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(3,4-methylenedioxyphenylmethyl) amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-[(S)-1-methylamino-2-methyl-1-oxo-2-butyl]amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(3S)-1,2-dioxo-1-[N-[(1RS)-1-methoxy-3-methyl-2-butyl]amino]-3-heptyl]-1-[N-(morpholine-4-carbo-nyl)amino]cyclohexanecarboxamide; N-[(3S)-1,2-dioxo-1-[N-[(1RS)-1-phenoxy-3-methyl-2-butyl]amino]-3-heptyl]-1-[N-(morpholine-4-carbo-nyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(3,4-methylenedioxyphenyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbo-nyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(2-benzothiazolyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(3S)-1,2-dioxo-1-[N-[(1S)-1-oxo-1-methoxy-3-phenyl-2-propyl]amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(3S)-1,2-dioxo-1-[N-[(R)-1-oxo-1-methoxy-3-methylthio-2-propyl]amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(3S)-1,2-dioxo-1-[N-[(S)-1,4-dioxo-1,4-dimethoxy-2-butyl]amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-[2-(3,4-methylenedioxyphenyl)ethyl]amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-(3,4-dimethoxyphenyl)amino]-3-heptyl]-1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxamide; N-[(S)-1,2-dioxo-1-[N-[2-(3,4-dimethoxyphenyl)ethyl]amino]-3-heptyl]-1-[N-(morpholine-4-carbo-nyl)amino]cyclohexanecarboxamide.

Verbindung, ausgewählt aus: Trans-4-[(8-Hydroxychinolin-2-ylmethyl)amino]cyclohexancarbonsäure(6-methoxy[1,5]-naphthyridin-4-yl)amid; Trans-4-[(Benzo[1,2,5]thiadiazol-5-ylmethyl)amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; Trans-4-[(1H-Pyrrolo[2,3-b]pyridin-2-ylmethyl)amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; Trans-4-[(3-Oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-ylmethyl)amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; Trans-4-[(2,3-Dihydrobenzo[1,4]dioxin-6-ylmethyl)amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; Trans-4-[(Benzo[1,2,3]thiadiazol-5-ylmethyl)amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; Trans-4-[(3-Methyl-2-oxo-2,3-dihydro-benzooxazol-6-ylmethyl)amin.o]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; Trans-4-[(3-Oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; Trans-4-[(7-Fluor-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)amino]cyclohexascarbonsäure(6-methoxy-[1,5]naphthyndm-4-yl)amid; Trans-4-[(2,3-Dihydrobenzo[1,4]dioxin-6-ylmethyl)amino]cyclohexancarbonsäure(8-fluor-6-methoxychinolin-4-yl)amid; Trans-4-[(2,3-Dihydrobenzo[1,4]dioxin-6-ylinethyl)amino]cyclohexancarbonsäure(6-methoxychinolin-4-yl)amid; Trans-4-[(Benzo[1,2,5]thiadiazol-5-ylmethyl)amino]cyclohexancarbonsäure(6-methoxychinolin-4-yl)amid; Trans-4-[(2-Oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazin-7-ylmethyl)amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; Trans-4-[(2-Oxo-2,3-dihydro-1H-pyndo[2,3-b][1,4]thiazin-7-ylmethyl)amino]cyclohexancarbonsäure(6-methoxychinolin-4-yl)amid; Trans-4-[(3,4-Dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)amino]cyclohexancarbonsäure-(6-methoxy-[1,5]naphthyridin-4-yl)amid; Trans-4-[(Thiazolo[5,4-b]pyndin-6-ylmethyl)amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; Trans-4-[(8-Hydroxy-1-oxo-1,2-dihydro-isochinolin-3-ylmethyl)amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; Trans-4-[(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-6-ylmethyl)amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; Trans-4-[(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; Trans-4-[(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-7-ylmethyl)amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; Trans-6-({4-[2-Hydroxy-2-(6-methoxychinolin-4-yl)ethyl]cyclohexylamino}methyl)-4-H-benzo[1,4]thiazin-3-on; Trans-2-{4-[(2,3-Dihydrobenzo[1,4]dioxin-6-ylmethyl)amino]cyclohexyl}-1-(6-methoxychinolin-4-yl)ethanol; Trans-4-[(6-Nitrobenzo[1,3]dioxol-5-ylmethyl)amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; Trans-4-[(6-Aminobenzo[1,3]dioxol-5-ylmethyl)amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; Trans-4-[(Benzothiazol-5-ylmethyl)amino]cyclohexancarbonsäure(6-methoxy-[1,5]-naphthyridin-4-yl)amid; Trans-4-[(4-Oxo-4H-pyrido[1,2-a]pyrimidin-2-ylmethyl)amino]cyclohexancarbonsäure-(6-methoxy-[1,5]naphthyridin-4-yl)amid; Trans-2-{4-[(2,3-Dihydrobenzo[1,4]dioxin-6-ylmethyl)amino]cyclohexyl}-1-(6-methoxychinolin-4-yl)-ethanon; Trans-4-[(3-Oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-ylinethyl)amino]cyclohexancarbonsäure(6-methoxychinolin-4-yl)amid; Trans-4-[(2,3-Dihydrobenzo[1,4]dioxin-6-ylmethyl)amino]cyclohexancarbonsäure[6-(3-aminopropoxy)-[l,5]naphthyridin-4-yl]amid; Trans-4-[(3-Oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-ylmethyl)amino]cyclohexancarbonsäure(8-fluor-6-methoxychinolin-4-yl)amid; Trans-4-[(3-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-ylmethyl)amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; Trans-4-[([1,2,3]Thiadiazolo[5,4-b]pyridin-6-ylmethyl)amino]cyclohexancarbonsäure (6-methoxy-[1,5]naphthyridin-4-yl)amid; Trans-4-(3-Oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-sulfonylamino)cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; Trans-4-[(7-Fluor-3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-ylmethyl)amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; Trans-4-[(8-Nitro-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6ylmethyl)amino]cyclohexancarbonsäure(6-methoxy)-[1,5]naphthyridin-4-yl)amid; Trans-4-[(8-Amino-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)amino]cyclohexancarbonsäure(6-methoxy)-[1,5]naphthyridin-4-yl)amid; (R/S)-4-[(3-Oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-ylmethyl)amino]cyclohex-1-encarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; (R/S)-4-[(Benzo[1,2,5]thiadiazol-5-ylmethyl)amino]cyclohexencarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; (R/S)-4-[(Benzo[1,2,3]thiadiazol-5-ylmethyl)amino]cyclohex-1-en-carbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; (R/S)-4-[(2-Oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazin-7-ylmethyl)amino]cyclohex-1-en-carbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; (R/S)-4-[(7-Fluor-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)amino]cyclohex-1-en-carbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; (R/S)-4-[(2-Oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-ylmethyl)amino]cyclohex-1-en-carbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; (R/S)-4-[Carboxymethyl-(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-ylmethyl)amino]-cyclohex-1-en-carbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; 1-Hydroxy-t-4-[(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-ylmethyl)amino]-r-cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; 1-Hydroxy-t-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)amino]-r-cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; 1-Hydroxy-t-4-[(2-oxo-2,3-dihydro-1H-pyrido[3,4-b][1,4]thiazin-7-ylmethyl)amino]-r-cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; 1-Hydroxy-t-4-[(2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazin-7-ylmethyl)amino]-r-cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; 1-Hydroxy-t-4-[(7-brom-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)-amino]-r-cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; 1-Hydroxy-t-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b] [1,4]oxazin-6-ylmethyl)amino]-r-cyclohexancarbonsäure(6-methoxy-[1,5]naphthyndin-4-yl)amid; 1-Hydroxy-t-4-[(7-chlor-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)-amino]-r-cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; 1-Hydroxy-t-4-[(7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-ylmethyl)amino]-r-cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; 1-Hydroxy-t-4-[(7-fluor-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)-amino]-r-cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; 1-Hydroxy-t-4-[(2-oxo-2,3-dihydro-1H-pyrido[3,4-b][1,4]oxazin-7-ylmethyl)amino]-r-cyclohexancarbonsäure(6-methyl-[1,5]naphthyridin-4-yl)amid; 1-Hydroxy-t-4-[(7-methyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)-amino]-r-cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; 1-Hydroxy-t-4-[(7-ethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)-amino]-r-cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; 1-Hydroxy-t-4-[(6-oxo-6,7-dihydro-5H-pyridazino[3,4-b][1,4]thiazin-3-ylmethyl)-amino]-r-cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; 1-Hydroxy-t-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)amino]-r-cyclohexancarbonsäure[6-(2-methoxyethoxy)-[1,5]naphthyridin-4-yl]amid; 1-Hydroxy-t-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)amino]-r-cylohexancarbonsäure(2,3-dihydro-[1,4]dioxino[2,3-f]chinolin-10-yl)amid; (1S,3S,4S)-3-Hydroxy-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)-amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; (1R,3R,4R)-3-Hydroxy-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)-amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; (1R,3R,4R)-3-Hydroxy-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)-amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; (1S,3S,4S)-3-Hydroxy-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)-amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; (1S,3S,4S)-4-[(7-Chlor-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)-amino]-3-hydroxycyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; (1R,3R,4R)-4-[(7-Chlor-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)-amino]-3-hydroxycyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; (1S,3S,4S)-3-Hydroxy-4-[(7-fluor-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; (1R,3R,4R)-3-Hydroxy-4-[(7-fluor-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; (1S,3S,4S)-3-Hydroxy-4-[(2-oxo-2,3-dihydro-1H-pyrido[3,4-b][1,4]oxazin-7-ylmethyl)-amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; (1R,3R,4R)-3-Hydroxy-4-[(2-oxo-2,3-dihydro-1H-pyrido[3,4-b][1,4]oxazin-7-ylmethyl)-amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; (1S,3S,4S)-3-Hydroxy-4-[(2-oxo-2,3-dihydro-1H-pyrido[3,4-b][1,4]thiazin-7-ylmethyl)-amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; (1R,3R,4R)-3-Hydroxy-4-[(2-oxo-2,3-dihydro-1H-pyrido[3,4-b][1,4]thiazin-7-ylmethyl)-amino]cylohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; (1S,3S,4S)-3-Hydroxy-4-[(6-oxo-6,7-dihydro-5H-8-thia-1,2,5-triaza-naphthalen-3-ylmethyl)amino]cylohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; (1R,3R,4R)-3-Hydroxy-4-[(6-oxo-6,7-dihydro-5H-8-thia-1,2,5-triaza-naphthalen-3-ylmethyl)amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; (1S,3S,4S)-3-Hydroxy-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)-amino]cyclohexancarbonsäure(6,8-difluorchinolin-4-yl)amid; (1R,3R,4R)-3-Hydroxy-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)-amino]cyclohexancarbonsäure(6,8-difluorchinolin-4-yl)amid; (1R,3R,4R)-3-Hydroxy-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yhneihyl)-amino]cylohexancarbonsäure(6-methoxy-[1,5]naphthyüdin-4-yl)amid; (1R,3R,4R)-3-Hydroxy-4-[(7-methyl-3,4-dihydro-2H-pyndo[3,2-b][1,4]thiazin-6-ylmethyl)amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; (1R,3R,4R)-3-Hydroxy-4-[(2-oxo-2,3-dihydro-1H-pyrido[3,4-b][1,4]thiazin-7-ylmethyl)-amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; (1S,3S,4S)-3-Hydroxy-4-[(7-methyl-3,4-dihydro-2H-pyndo[3,2-b][1,4]thiazin-6-ylmethyl)amino]cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; (1S,3S,4S)-3-Hydroxy-4-[(2-oxo-2,3-dihydro-1H-pyrido[3,4-b][1,4]thiazin-7-ylmethyl)amino] cyclohexancarbonsäure(6-methoxy-[1,5]naphthyridin-4-yl)amid; 1-Hydroxy-t-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)amino-r-cyclohexancarbonsäure(8-fluor-6-methoxychinolin-4-yl)amid; 1-Hydroxy-t-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)amino-r-cyclohexancarbonsäure(6-methoxychinolin-4-yl)amid; 1-Hydroxy-t-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)amino-r-cyclohexancarbonsäure(6,8-difluor-chinolin-4-yl)amid; 6-({4-Hydroxy-4-[2-(6-methoxy-[1,5]naphthyridin-4-yl)ethyl]cyclohexylamino}methyl)-4H-pyrido[3,2-b][1,4]oxazin-3-on; cis-4-[(2,3-Dihydro[1,4]dioxin[2,3-c]pyridin-7-ylmethyl)amino]-1-hydroxy-N-[6-(methyloxy)-1,5-naphthyridin-4-yl]cyclohexancarboxamid; einer Verbindung der Tabelle A, B, C, D, E, F oder G: oder ein pharmazeutisch verträgliches Derivat davon.

A compound selected from: Trans-4-[(8-Hydroxy-quinolin-2-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide Trans-4-[(Benzo[1,2,5]thiadiazol-5-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(1H-Pyrrolo[2,3-b]pyridin-2-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(3-Oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-ylmethyl)-amino]-cyclohexane carboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(2,3-Dihydro-benzo[1,4]dioxin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(Benzo[1,2,3]thiadiazol-5-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(3-Methyl-2-oxo-2,3-dihydro-benzooxazol-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(3-Oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(7-Fluoro-3-oxo-3,4-dihydro-2H-benzg[1,4]oxazin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(2,3-Dihydro-benzo[1,4]dioxin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (8-fluoro-6-methoxy-quinolin-4-yl)-amide; Trans-4-[(2,3-Dihydro-benzo[1,4]dioxin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-quinolin-4-yl)-amide; Trans-4-[(Benzo[1,2,5]thiadiazol-5-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-quinolin-4-yl)-amide; Trans-4-[(2-Oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazin-7-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(2-Oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazin-7-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-quinolin-4-yl)-amide; Trans-4-[(3,4-Dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(Thiazolo[5,4-b]-pyridin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(8-Hydroxy-1-oxo-1,2-dihydro-isoquinolin-3-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-7-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-6-({4-[2-Hydroxy-2-(6-methoxy-quinolin-4-yl)-ethyl]-cyclohexylamino}-methyl)-4-H-benzo[1,4]thiazin-3-one; Trans-2-{4-[(2,3-Dihydro-benzo[1,4]dioxin-6-ylmethyl)-amino]-cyclohexyl}-1-(6-methoxy-quinolin-4-yl)-ethanol; Trans-4-[(6-Nitro-benzo[1,3]dioxol-5-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyrioin-4-yl)-amide; Trans-4-[(6-Amino-benzo[1,3]dioxol-5-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(Benzothiazol-5-ylmethyl)-amino]cyclohexanecarboxylic acid(6-methoxy-[1,5]naphthyridin-4-yl)amide; Trans-4-[(4-Oxo-4H-pyridio[1,2-a]pyrimidin-2-ylmethyl)-amino]-cyclohexancarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-2-{4-[(2,3-Dihydro-benzo[1,4]dioxin-6-ylmethyl)-amino]-cyclohexyl}-1-(6-methoxy-quinolin-4-yl)-ethanone; Trans-4-[(3-Oxo-3,4-dihydro-2-1 H -benzo[1,4]thiazin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-quinolin-4-yl)-amide; Trans-4-[(2,3-Dihydro-benzo[1,4]dioxin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid [6-(3-amino-propoxy)-[1,5]naphthyridin-4-yl]-amide; Trans-4-[(3-Oxo-3,4-dihydro-2 H -benzo[1,4]thiazin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (8-fluoro -6-methoxy-quinolin-4-yl)-amide; Trans-4-[(3-Oxo-3,4-dihydro-2 H -pyrido[3,2-b][1,4]oxazin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[([1,2,3]Thiadiazolo[5,4-b]pyridin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-(3-Oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-sulfonylamino)-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(7-Fluoro-3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(8-Nitro-3-oxo-3,4-dihydro-2 H -benzo[1,4]oxazin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy)-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(8-Amino-3-oxo-3,4-dihydro-2 H -benzo[1,4]oxazin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy)-[1,5]naphthyridin-4-yl)-amide; (R/S)4-[(3-Oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-ylmethyl)-amino]-cyclohex-1-ene carboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (R/S)-4-[(Benzo[1,2,5]thiadiazol-5-ylmethyl)-amino]-cyclohexene carboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (R/S)-4-[(Henzo[1,2,3]thiadiazol-5-ylmethyl)-amino]-cyclohex-1-ene carboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)amide; (R/S)-4-[(2-Oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazin-7-ylmethyl)-amino]-cyclohex-1-ene carboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (R/S)-4-[(7-Fluoro-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)-amino]-cyclohex-1-ene carboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (R/S)-4-[(2-Oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-ylmethyl)-amino]-cyclohex-1-ene carboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (R/S)-4-[Carboxymethyl-(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-ylmethyl)-amino]-cyclohex-1-ene carboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy-t-4-[(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-ylmethyl)-amino]-r-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy- t -4-[(3-oxo-3,4-dihydro-2 H -pyrido[3,2- b ][1,4]thiazin-6-ylmethyl)-amino]- r- cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy- t -4-[(2-oxo-2,3-dihydro-1 H -pyrido[3,4- b ][1,4]thiazin-7-ylmethyl)-amino]- r- cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy- t -4-[(2-oxo-2,3-dihydro-1 H -pyrido[2,3- b ][1,4]thiazin-7-ylmethyl)-amino]- r- cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy- t -4-[(7-bromo-3-oxo-3,4-dihydro-2 H -pyrido[3,2- b ][1,4]thiazin-6-ylmethyl)-amino]- r -cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy- t -4-[(3-oxo-3,4-dihydro-2 H -pyrido[3,2- b ][1,4]oxazin-6-ylmethyl)-amino]- r- cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy-t-4-[(7-chloro-3-oxo-3,4-dihydro-2 H -pyrido[3,2- b ][1,4]thiazin-6-ylmethyl)-amino]-r-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy-t-4-[(7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridine-2-ylmethyl)-amino]-r-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridine-4-yl)-amide; 1-Hydroxy-t-4-[(7-fluoro-3-oxo-3,4-dihydro-2 H -pyrido[3,2- b ][1,4]thiazin-6-ylmethyl)-amino]-r-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy-t-4-[(2-oxo-2,3-dihydro-1 H -pyrido[3,4- b ][1,4]oxazin-7-ylmethyl)-amino]- r- cyclohexanecarboxylic acid (6-methyl-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy- t -4-[(7-methyl-3-oxo-3,4-dihydro-2 H -pyrido[3,2- b ][1,4]thiazin-6-ylmethyl)-amino]-r-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy- t -4-[(7-ethyl-3-oxo-3,4-dihydro-2 H -pyrido[3,2- b ][1,4]thiazin-6-ylmethyl)-amino]- r -cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy- t -4-[(6-oxo-6,7-dihydro-5 H -pyridazino[1,4- b ][1,4]thiazin-3-ylmethyl)-amino]- r -cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy- t -4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2- b ][1,4]thiazin-6-ylmethyl)-amino]- r- cyclohexanecarboxylic acid [6-(2-methoxy-ethoxy)-[1,5]naphthyridin-4-yl]-amide; 1-Hydroxy- t -4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2- b ][1,4]thiazin-6-ylmethyl)-amino]- r- cyclohexanecarboxylic acid (2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)-amide; (1S,3S,4S)-3-Hydroxy-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1R,3R,4R)-3-Hydroxy-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1R,3R,4R)-3-Hydroxy-4-[(3-oxo-3,4-dihydro-2 H pyrido[3,2- b ][1,4]thiazin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1S,3S,4S)-3-Hydroxy-4-[(3-oxo-3,4-dihydro-2 H pyrido[3,2- b ][1,4]thiazin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1S,3S,4S)-4-[(7-Chloro-3-oxo-3,4-dihydro-2H-pyrido[3,2-b] [1,4]thiazin-6-ylmethyl)-amino]-3-hydroxy-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1R,3R,4R)-4-[(7-Chloro-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)-amino]-3-hydroxy-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1S,3S,4S)-3-Hydroxy-4-[(7-fluoro-3-oxo-3,4-dihydro-2 H -pyrido[3,2- b ][1,4]thiazin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1R,3R,4R)-3-Hydroxy-4-[(7-fluoro-3-oxo-3,4-dihydro-2 H -pyrido[3,2- b ][1,4]thiazin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1S,3S,4S)-3-Hydroxy-4-[(2-oxo-2,3-dihydro-1 H -pyrido[3,4-b] [1,4]oxazin-7-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1R,3R,4R)-3-Hydroxy-4-[(2-oxo-2,3-dihydro- 1 H -pyrido[3,4- b ][1,4]oxazin-7-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1S,3S,4S)-3-Hydroxy-4-[(2-oxo-2,3-dihydro-1 H- pyrido[3,4- b ][1,4]thiazin-7-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1R,3R,4R)-3-Hydroxy-4-((2-oxo-2,3-dihydro-1 H -pyrido[3,4- b ][1,4]thiazin-7-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1S,3S,4S)-3-Hydroxy-4-[(6-oxo-6,7-dihydro-5H-8-thia-1,2,5-triaza-naphthalen-3-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1R,3R,4R)-3-Hydroxy-4-[(6-oxo-6,7-dihydro-5H-8-thia-1,2,5-triaza-naphthalen-3-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1S,3S,4S)-3-Hydroxy-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6,8-difluoro-quinolin-4-yl)-amide; (1R,3R,4R)-3-Hydroxy-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6,8-difluoroquinolin-4-yl)-amide; (1R,3R,4R)-3-Hydroxy-4-[(3-oxo-3,4-dihydro-2 H -pyrido[3,2- b ][1,4]oxazin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1R,3R,4R)-3-Hydroxy-4-[(7-methyl-3,4-dihydro-2 H -pyrido[3,2- b ][1,4]thiazin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1R,3R,4R)-3-Hydroxy-4-[(2-oxo-2,3-dihydro-1 H -pyrido[3,4-b][1,4]thiazin-7-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin4-yl)-amide; (1S,3S,4S)-3-Hydroxy-4-[(7-methyl-3,4-dihydro-2 H -pyrido[3,2-b][1,4]thiazin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1S,3S,4S)-3-Hydroxy-4-[(2-oxo-2,3-dihydro-1 H -pyrido[3,4- b ][1,4]thiazin-7-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy-t-4-[(3-oxo-3,4-dihydro-2 H -pyrido[3,2- b ][1,4]thiazin-6-ylmethyl)-amino-r-cyclohexanecarboxylic acid (8-fluoro-6-methoxy-quinolin-4-yl)-amide; 1-Hydroxy-t-4-[(3-oxo-3,4-dihydro-2 H -pyrido[3,2- b ][1,4]thiazin-6-ylmethyl)-ainino-r-cyclohexanecarboxylic acid (6-methoxy-quinolin-4-yl)-amide; 1-Hydroxy-t-4-[(3-oxo-3,4-dihydro-2 H -pyrido[3,2- b ][1,4]thiazin-6-ylmethyl)-amino-r-cyclohexanecarboxylic acid (6,8-difluoro-qumolin-4-yl)-amide; 6-({4-Hydroxy-4-[2-(6-methoxy-[1,5]naphthyridin-4-yl)-ethyl]-cyclohexylamino}-methyl)-4H-pyrido[3,2-b][1,4]oxazin-3-one; cis-4-[(2,3-Dihydro[1,4]dioxino[2,3-c]pyndin-7-ylmethyl)amino]-1-hydroxy-N-[6-(methyloxy)-1,5-naphthyridin-4-yl]cyclohexanecarboxamide; a compound of Table A, B, C, D, E, F or G: or a pharmaceutically acceptable derivative thereof.

Kombination einer Verbindung der Formel (1.0.0), wie sie in einem der Ansprüche 1 bis 6 definiert ist, zusammen mit einem Glied oder mehreren Gliedern, ausgewählt aus der Gruppe bestehend aus folgenden: (a) Leukotrienbiosynthese-Inhibitoren, 5-Lipoxygenase(5-LO)-Inhibitoren und 5-Lipoxygenase-Aktivierungsprotein(FLAP)-Antagonisten, ausgewählt aus der Gruppe bestehend aus Zileuton; ABT-761; Fenleuton; Tepoxalin; Abbott-79175; Abbott-85761; N-(5-substituierten) Thiophen-2-alkylsulfonamiden der Formel (5.2.8); 2,6-Di-tert.-butylphenolhydrazonen der Formel (5.2.10); Zeneca ZD-2138 der Formel (5.2.11); SB-210661 der Formel (5.2.12); Pyridinylsubstituierter 2-Cyanonaphthalinverbindung L-739.010; 2-Cyanochinolinverbindung L-746.530; Indol- und Chinolin-Verbindungen MK-591, MK-886 und BAY x 1005; (b) Rezeptor-Antagonisten für Leukotriene LTB4, LTC4, LTD4 und LTE4, ausgewählt aus der Gruppe bestehend aus Phenothiazin-3-on-Verbindung L-651.392; Amidinoverbindung CGS-25019c; Benzoxazolaminverbindung Ontazolast; Benzolcarboximidamidverbindung BIIL 284/260; den Verbindungen Zafirlukast, Ablukast, Montelukast, Pranlukast, Verlukast (MK-679), RG-12525, Ro-245913, Iralukast (CGP 45715A) und BAY x 7195; (c) PDE4-Inhibitoren; (d) 5-Lipoxygenase(5-LO)-Inhibitoren; und 5-Lipoxygenase-Aktivierungsprotein(FLAP)-Antagonisten; (e) dualen Inhibitoren von 5-Lipoxygenase(5-LO) und Antagonisten von Thrombozyten-Aktivierungsfaktor (PAF); (f) Leukotrien-Antagonisten (LTRAs) von LTB4, LTC4, LTD4 und LTE4; (g) antihistaminischen H1-Rezeptor-Antagonisten Cetirizin, Loratadin, Desloratadin, Fexofenadin, Astemizol, Azelastin und Chlorpheniramin; (h) gastroprotektiven H2-Rezeptor-Antagonisten; (i) ?1- und ?2-Adrenozeptor-Agonist-Vasokonstriktor-Sympathomimetika, oral oder topisch zur Verwendung, als Dekongestionsmittel verabreicht, ausgewählt aus der Gruppe bestehend aus Propylhexedrin, Phenylephrin, Phenylpropanolamin, Pseudoephedrin, Naphazolinhydrochlorid, Oxymetazolinhydrochlorid, Tetrahydrozolinhydrochlorid, Xylometazolinhydrochlorid und Ethylnorepinephrinhydrochlorid; (j) einen oder mehreren ?1- und ?2-Adrenozeptor-Agonist(en), wie oben in (i) angegeben, in Kombination mit einem oder mehreren Inhibitor(en) von 5-Lipoxygenase(5-LO), wie oben in (a) angegeben; (k) anticholinergen Agentien Ipratropiumbromid; Tiotropiumbromid; Oxitropiumbromid; Pirenzepin; und Telenzepin; (l) ?1- bis ?4-Adrenozeptor-Agonisten, ausgewählt aus der Gruppe, bestehend aus Metaproterenol, Isoproterenol, Isoprenalin, Albuterol, Salbutamol, Formoterol, Salmeterol, Terbutalin, Orciprenalin, Bitolterol und Pirbuterol; (m) Theophyllin und Aminophyllin; (n) Natriumcromoglykat; (o) muskarinergem Rezeptor (M1, M2 und M3)-Antagonisten; (p) COX-1-Inhibitoren (NSAIDs); und Stickoxid-NSAIDs; (q) Cox-2-selektivem Inhibitor Rofecobix; (r) Insulin-artigem Wachstumsfaktor, Typ I(IGF-1)-Mimetika; (s) Ciclesonid; (t) inhalierten Glucocorticoiden mit reduzierten systemischen Nebenwirkungen, ausgewählt aus der Gruppe bestehend aus Prednison, Prednisolon, Flunisolid, Triamcinolon, Acetonid, Beclomethasondipropionat, Budesonid, Fluticasonpropionat und Mometasonfuroat; (u) Tryptase-Inhibitoren; (v) Thrombozyten-Aktivierungsfaktor(PAF)-Antagonisten; (w) monoklonalen Antikörpern, die gegen endogene inflammatorische Einheiten aktiv sind; (x) IPL 576; (y) Antitumor-Nekrosefaktor(TNF?)-Agentien, ausgewählt aus der Gruppe bestehend aus Etanercept, Infliximab und D2E7; (z) DMARDs, ausgewählt aus der Gruppe bestehend aus Leflunomid;

The combination of a compound of Formula (1.0.0) as defined in any of claims 1 to 6 together with one or more members selected from the group consisting of the following: (a) Leukotriene biosynthesis inhibitors, 5-lipoxygenase (5-LO) inhibitors, and 5-lipoxygenase activating protein (FLAP) antagonists selected from the group consisting of zileuton; ABT-761; fenleuton; tepoxalin; Abbott-79175; Abbott-85761; N-(5-substituted)-thiophene-2-alkylsulfonamides of Formula (5.2.8); 2,6-di-tert-butylphenol hydrazones of Formula (5.2.10); Zeneca ZD-2138 of Formula (5.2.11); SB-210661 of Formula (5.2.12); pyridinyl-substituted 2-cyanonaphthalene compound L-739,010; 2-cyanoquinoline compound L-746,530; indole and quinoline compounds MK-591, MK-886, and BAY x 1005; (b) Receptor antagonists for leukotrienes LTB4, LTC4, LTD4, and LTE4 selected from the group consisting of phenothiazin-3-one compound L-651,392; amidino compound CGS-25019c; benzoxazolamine compound ontazolast; benzenecarboximidamide compound BIIL 284/260; compounds zafirlukast, ablukast, montelukast, pranlukast, verlukast (MK-679), RG-12525, Ro-245913, iralukast (CGP 45715A), and BAY x 7195; (c) PDE4 inhibitors; (d) 5-Lipoxygenase (5-LO) inhibitors; and 5-lipoxygenase activating protein (FLAP) antagonists; (e) Dual inhibitors of 5-lipoxygenase (5-LO) and antagonists of platelet activating factor (PAF); (f) Leukotriene antagonists (LTRAs) of LTB4, LTC4, LTD4, and LTE4; (g) Antihistaminic H1 receptor antagonists cetirizine, loratadine, desloratadine, fexofenadine, astemizole, azelastine, and chlorpheniramine; (h) Gastroprotective H2 receptor antagonists; (i) ?1- and ?2-adrenoceptor agonist vasoconstrictor sympathomimetic agents administered orally or topically for decongestant use, selected from the group consisting of propylhexedrine, phenylephrine, phenylpropanolamine, pseudoephedrine, naphazoline hydrochloride, oxymetazoline hydrochloride, tetrahydrozoline hydrochloride, xylometazoline hydrochloride, and ethylnorepinephrine hydrochloride; (j) one or more ?1-and ?2-adrenoceptor agonists as recited in (i) above in combination with one or more inhibitors of 5-lipoxygenase (5-LO) as recited in (a) above; (k) Anticholinergic agents ipratropium bromide; tiotropium bromide; oxitropium bromide; pirenzepine; and telenzepine; (l) ?1- to ?4-adrenoceptor agonists selected from the group consisting of metaproterenol, isoproterenol, isoprenaline, albuterol, salbutamol, formoterol, satmeterol, terbutaline, orciprenaline, bitolterol, and pirbuterol; (m)Theophylline and aminophylline; (n) Sodium cromoglycate; (o) Muscarinic receptor (M1, M2, and M3) antagonists; (p) COX-1 inhibitors (NSAIDs); and nitric oxide NSAIDs; (q) COX-2 selective inhibitor rofecoxib; (r) Insulin-like growth factor type I (IGF-1) mimetics; (s) Ciclesonide; (t) Inhaled glucocorticoids with reduced systemic side effects selected from the group consisting of prednisone, prednisolone, flunisolide, triamcinolone acetonide, beclomethasone dipropionate, budesonide, fluticasone propionate, and mometasone furoate; (u) Tryptase inhibitors; (v) Platelet activating factor (PAF) antagonists; (w)Monoclonal antibodies active against endogenous inflammatory entities; (x) IPL 576; (y) Anti-tumor necrosis factor (TNF?) agents selected from the group consisting of etanercept, infliximab, and D2E7; (z) DMARDs selected from the group consisting of leflunomide;

Verwendung nach einem der Ansprüche 1 bis 17, wobei die Verbindung ausgewählt ist aus der Gruppe, die besteht aus: N-{5-[1-(4-tert-Butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-{5-[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-{5-[1-(4-tert-Butylphenyl)-5-pyridin-3-yl-1H-pyrazol-3-yl]pentanoyl}tyrosinamid; N-{5-[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-{5-[1-(4-tert-Butylphenyl)-5-pyridin-4-yl-1H-pyrazol-3-yl]pentanoyl}tyrosinamid; N-{5-[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]pentanoyl}-N,N-dimethyltyrosinamid; N-(3-[1-(4-tert-Butylphenyl)-5-pyridin-3-yl-1H-pyrazol-3-yl]propanoyl)tyrosinamid; N-(3-[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]propanoyl)tyrosinamid; N-[4-(1-Butyl-3-isochinolin-3-yl-1H-pyrazol-5-yl)benzoyl]tyrosinamid; N-{5-[1-(4-lsopropylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-{6-[1-(4-lsopropylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}tyrosinamid; N-{6-[1-(4-tert-Butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}-3-hydroxyphenylalaninamid; N-[1-(Aminocarbonyl)-3-(4-hydroxyphenyl)propyl]-5-[1-(4-tert-Butylphenyl)-3-pyridin-2-yl-1 H-pyrazol-5-yl]pentanamid; N-[5-(1-Butyl-3-isochinolin-3-yl-1H-pyrazol-5-yl)pentanoyl]tyrosinamid; N-{6-[1-(4-tert-Butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}serinamid; N-{6-[1-(4-lso-propylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}serinamid; N-{6-[1-(4-lso-propylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}threonamid; N-{5-[1-(4-Isopropylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; 6-[1-(4-tert-Butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]-N-[2-(4-hydroxyphenyl)-ethyl]hexanamid; N-{6-[1-(4-tert-Butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}tyrosinamid; N-{5-[1-(4-tert-Butylphenyl)-3-isochinolin-3-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-{6-[1-(4-tert-Butylphenyl)-3-isochinolin-3-yl-1H-pyrazol-5-yl]hexanoyl}tyrosinamid; N-{6-[1-(4-tert-Butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}-N-methyltyrosinamid; N-{6-[1-(4-tert-Butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}-4-(hydroxymethyl)phenylalaninamid; 4-Amino-N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}phenylalaninamid; 4-(Acetylamino)-N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}phenylalaninamid; 4-(Aminocarbonyl)-N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}phenylalaninamid; N-Butyl-N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}tyrosinamid; N-{6-[1-(4-tert-Butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}threonamid; N-[2-Amino-1-(4-hydroxyphenyl)-2-oxoethyl]-6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanamid; N-({5-[1-(4-Isopropylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]thien-2-yl}carbonyl)tyrosinamid; N-[2-Amino-1-(4-hydroxyphenyl)-2-oxoethyl]-4-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]benzamid; 4-[1-(4-tert-Butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]-N-[2-(4-hydroxyphenyl)ethyl]benzamid; N-{3-[1-(4-tert-Butylbenzyl)-3-isochinolin-3-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamid; N-{5-[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-{3-[1-(4-tert-Butylbenzyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamid; N-{3-[1-(4-tert-Butylphenyl)-3-isochinolin-3-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamid; N-[4-(1-Butyl-3-isochinolin-3-yl-1H-pyrazol-5-yl)benzoyl]tyrosinamid; N-{3-[1-(4-tert-Butylbenzyl)-3-chinolin-3-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamid; N-{3-[3-Isochinolin-3-yl-1-(4-propylphenyl)-1H-pyrazol-5-yl]benzoyl}tyrosinamid; N-{5-[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-{3-[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamid; N-{4-[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamid; N-{5-[1-(4-tert-Butylbenzyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-{3-[1-(4-tert-Butylbenzyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamid; N-{5-[1-(4-tert-Butylbenzyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-{5-[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-[3-(1-Butyl-3-isochinolin-3-yl-1H-pyrazol-5-yl)benzoyl]tyrosinamid; N-(4-{[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}butanoyl)-tyrosinamid; N-({3-[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]propoxy}acetyl)tyrosinamid; 4-[2-({3-[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]propyl}amino)ethyl]-phenol; N-{3-[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]propyl}tyrosinamid; N-Acetyl-N-{3-[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]propyl}tyrosinamid; 3-[(4-{[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}butanoyl)amino]-4-(4-hydroxyphenyl)butanamid; N-(4-{[1-(4-tert-Butylphenyl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrazol-5-yl]amino}butanoyl)tyrosinamid; N-(3-{[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}propyl)-tyrosinamid; N-Acetyl-N-(3-{[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}propyl)-tyrosinamid; N-(4-{[1-(4-tert-Butylphenyl)-3-(1-oxidopyridin-4-yl)-1H-pyrazol-5-yl]amino}butanoyl)tyrosinamid; 4-{[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}-N-[2-(4-hydroxyphenyl)ethyl]butanamid; 4-{2-[(4-{[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}butyl)amino]ethyl}phenol; N-(4-{[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}butanoyl)-N-(2-hydroxyethyl)tyrosinamid; N-(4-{[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}butanoyl)-N-[2-(1-methylpyrrolidin-2-yl)ethyl]tyrosinamid; N-(4{[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}butanoyl)tyrosinamid; N-(4-{[1-(4-tert-Butylphenyl)-3-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1H-pyrazol-5-yl]amino}butanoyl)tyrosinamid; (3R)-3-[(4-{[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}butanoyl)amino]-4-(4-hydroxyphenyl)butanamid; N-(3-{[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}propyl)-tyrosinamid; N-Acetyl-N-(3-{[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}propyl)-tyrosinamid; N-(4-{[1-(4-tert-Butylphenyl)-3-(1-oxidopyridin-3-yl)-1H-pyrazol-5-yl]amino}butanoyl)tyrosinamid; 4-{[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}-N-[2-(4-hydroxyphenyl)ethyl]butanamid; 4-{2-[(4-{[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}butyl)amino]-ethyl}phenol; N-(4-{[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}butanoyl)-N-(2-hydroxyethyl)tyrosinamid; N-(4-{[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}butanoyl)-N-[2-(1-methylpyrrolidin-2yl)ethyl]tyrosinamid; N-(4-{[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]oxy}butanoyl)-tyrosinamid; oder ein optisches Isomer, Racemat oder Tautomer von irgendeinem davon oder ein pharmazeutisch verträgliches Salz von irgendeinem davon.

The use according to any one of claims 1 to 17 wherein the compound is selected from the group consisting of: N-{5-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamide; N-{5-[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamide; N-{5-[1-(4-tert.butylphenyl)-5-pyridin-3-yl-1H-pyrazol-3-yl]pentanoyl}tyrosinamide; N-{5-[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamide; N-{5-[1-(4-tert-butylphenyl)-5-pyridin-4-yl-1H-pyrazol-3-yl]pentanoyl}tyrosinamide; N-{5-[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]pentanoyl}-N,Ndimethyl tyrosinamide; N-(3-[1-(4-tert-butylphenyl)-5-pyridin-3-yl-1H-pyrazol-3-yl]propanoyl)tyrosinamide; N-(3-[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]propanoyl)tyrosinamide; N-[4-(1-butyl-3-isoquinolin-3-yl-1H-pyrazol-5-yl)benzoyl]tyrosinamide; N-{5-[1-(4-isopropylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamide; N- {6-[1-(4-isopropylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}tyrosinamide N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}-3-hydroxy phenylalaninamide; N-[1-(aminocarbonyl)-3-(4-hydroxyphenyl)propyl]-5-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]pentanamide; N-[5-(1-butyl-3-isoquinolin-3-yl-1H-pyrazol-5-yl)pentanoyl]tyrosinamide; N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}serinamide; N-{6-[1-(4-iso-propylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}serinamide; N-{6-[1-(4-iso-propylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}threonamide; N-{5-[1-(4-isopropytphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamide; 6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]-N-[2-(4-hydroxyphenyl) ethyl]hexanamide; N- {6-[1-(4-tert-butytphenyl)-3-pyridin-2-yl-1 H-pyrazol-5-yl]hexanoyl} tyrosinamide; N-{5-[1-(4-tert-butylphenyl)3-isoquinolin-3-yl-1H-pyrazol-5-yl]pentanoyl} tyrosinamide; N-{6-[1-(4-tert-butylphenyl)-3-isoquinolin-3-yl-1H-pyrazol-5-yl]hexanoyl} tyrosinamide; N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}-N-methyl tyrosinamide; N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}-4-(hydroxymethyl)phenylalaninamide; 4-amino-N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl} phenylalaninamide; 4-(acetylamino)-N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl] hexanoyl}phenylalaninamide; 4-(aminocarbonyl)-N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl] hexanoyl}phenylaninamide ; N-butyl-N-{6-[1-(4-tert-butylphenyl)-pyridin-2-yl-1H-pyrazol-5-yl] hexanoyl}tyrosinamide; N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}threonamide; N-[2-amino-1-(4-hydroxyphenyl)-2-oxoethyl]-6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanamide; N-({5-[1-(4-isopropylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]thien-2-yl}carbonyl) tyrosinamide; N-[2-amino-1-(4-hydroxyphenyl)-2-oxoethyl]-4-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]benzamide; 4-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]-N-[2-(4-hydroxyphenyl) ethyl]benzamide; N-{3-[1-(4-tert-butylbenzyl)-3-isoquinolin-3-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamide; N-{5-[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamide; N-{3-[1-(4-tert-butylbenzyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]benzol}tyrosinamide; N-{3-[1-(4-tert-butylphenyl)-3-isoquinolin-3-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamide; N-[4-(1-butyl-3-isoquinolin-3-yl-1H-pyrazol-5-yl)benzoyl]tyrosinamide; N-{3-[1-(4-tert-butybenzyl)-3-quinolin-3-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamide; N-{3-[3-isoquinolm-3-yl-1-(4-propylphenyl)-1H-pyrazol-5-yl]benzoyl}tyrosinamide; N-{5-[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-l]pentanoyl} tyrosinamide; N-{3-[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamide; N-{4-[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamide; N-{5-[1-(4-tert-butylbenzyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamide; N-{3-[1-(4-tert-butylbenzyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamide; N-{5-[1-(4-tert-butylbenzyl)-3-pyridin-3-yl-1H-pyrazol-5-l]pentanoyl}tyrosinamide; N-{5-[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamide; N-[3-(1-butyl-3-isoquinolin-3-yl-1H-pyrazol-5-yl)benzoyl]tyrosinamide; N-(4-{[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}butanoyl) tyrosinamide; N-({3-[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]propoxy}acetyl) tyrosinamide; 4-[2-({3-[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]propyl}amino)ethyl] phenol; N-{3-[1-(4-tert-butylpbenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]propyl}tyrosinamide; N-acetyl-N-{3-[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]propyl} tyrosinamide; 3-[(4-{[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}butanoyl)amino]-4-(4-hydroxyphenyl)butanamide; N-(4-{[1-(4-tert-butylphenyl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrazol-5-yl]amino}butanoyl)tyrosinamide; N-(3- {[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}propyl) tyrosinamide; N-acetyl-N-(3-{[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}propyl) tyrosinamide; N-(4-{[1-(4-tert-butylphenyl)-3-(1-oxidopyridin-4-yl)-1H-pyrazol-5-yl]amino} butanoyl)tyrosinamide; 4-{[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}-N-[2-(4-hydroxy phenyl)ethyl]butanamide; 4- {2-[(4-{[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}butyl)amino] ethyl}phenol; N-(4-{[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}butanoyl)-N-(2-hydroxyethyl)tyrosinamide; N-(4-{[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}butanoyl)-N-[2-(1-methylpyrrolidin-2-yl)ethyl]tyrosinamide; N-(4-{[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}butanoyl) tyrosinamide; N-(4-{[1-(4-tert-butylphenyl)-3-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1H-pyrazol-5-yl]amino}butanoyl)tyrosinamide; (3R)-3-[(4-{[1-(4-tet-butytphenyl)-3-pyhdin-3-yl-1H-pyrazol-5-yl]amino}butanoyl) amino]-4-(4-hydroxyphenyl)butanamide; N-(3-{[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}propyl) tyrosinamide; N-acetyl-N-(3-{[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino} propyl) tyrosinamide ; N-(4-{[1-(4-tert-butylphenyl)-3-(1-oxidopyridin-3-yl)-1H-pyrazol-5-yl]amino}butanoyl) tyrosinamide; 4- {[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}-N-[2-(4-hydroxy phenyl)ethyl] butanamide; 4-{2-[(4-{[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}butyl)amino] ethyl}phenol; N-(4-{[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}butanoyl)-N-(2-hydroxyethyl)tyrosinamide; N-(4-{[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}butanoyl)-N-[2-(1-methylpyrrolidin-2-yl)ethyl]tyrosinamide; N-(4-{(1-(4-tert-butylphenyl)-3-pyrldin-3-yl-1H-pyrazol-5-yl)oxy}butanoyl) tyrosinamide; or an optical isomer, racemate or tautomer of any one thereof or a pharmaceutically acceptable salt of any one thereof.

Verbindung nach einem der Ansprüche 28 bis 44, wobei die Verbindung ausgewählt wird aus der Gruppe, bestehend aus: N-{5-[1-(4-tert-Butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-{5-[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-{5-[1-(4-tert-Butylphenyl)-5-pyridin-3-yl-1H-pyrazol-3-yl]pentanoyl}tyrosinamid; N-{5-[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-{5-[1-(4-tert-Butylphenyl)-5-pyridin-4-yl-1H-pyrazol-3-yl]pentanoyl}tyrosinamid; N-{5-[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]pentanoyl}-N,N-dimethyltyrosinamid; N-(3-[1-(4-tert-Butylphenyl)-5-pyridin-3-yl-1H-pyrazol-3-yl]propanoyl)tyrosinamid; N-(3-[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]propanoyl)tyrosinamid; N-[4-(1-Butyl-3-isochinolin-3-yl-1H-pyrazol-5-yl)benzoyl]tyrosinamid; N-{5-[1-(4-Isopropylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-{6-[1-(4-Isopropylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}tyrosinamid; N-{6-[1-(4-tert-Butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}-3-hydroxyphenylalaninamid; N-[1-(Aminocarbonyl)-3-(4-hydroxyphenyl)propyl]-5-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1 H-pyrazol-5-yl]pentanamid; N-[5-(1-Butyl-3-isochinolin-3-yl-1H-pyrazol-5-yl)pentanoyl]tyrosinamid; N-{6-[1-(4-tert-Butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}serinamid; N-{6-[1-(4-Isopropylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}serinamid; N-{6-[1-(4-Isopropylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}threonamid; N-{5-[1-(4-Isopropylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; 6-[1-(4-tert-Butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]-N-[2-(4-hydroxyphenyl) ethyl]hexanamid; N-{6-[1-(4-tert-Butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}tyrosinamid; N-{5-[1-(4-tert-Butylphenyl)-3-isochinolin-3-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-{6-[1-(4-tert-Butylphenyl)-3-isochinolin-3-yl-1H-pyrazol-5-yl]hexanoyl}tyrosinamid; N-{6-[1-(4-tert-Butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}-N-methyltyrosinamid; N-{6-[1-(4-tert-Butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}-4-(hydroxymethyl)phenylalaninamid; 4-Amino-N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl} phenylalaninamid; 4-(Acetylamino)-N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl} phenylalaninamid; 4-(Aminocarbonyl)-N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl] hexanoyl}phenylalaninamid; N-Butyl-N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}tyrosinamid; N-{6-[1-(4-tert-Butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}threonamid; N-[2-Amino-1-(4-hydroxyphenyl)-2-oxoethyl]-6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1 H-pyrazol-5-yl]hexanamid; N-({5-[1-(4-Isopropylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]-thien-2-yl}carbonyl)tyrosinamid; N-[2-Amino-1-(4-hydroxyphenyl)-2-oxoethyl]-4-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1 H-pyrazol-5-yl]benzamid; 4-[1-(4-tert-Butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]-N-[2-(4-hydroxyphenyl) ethyl]benzamid; N-{3-[1-(4-tert-Butylbenzyl)-3-isochinolin-3-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamid; N-{5-[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-{3-[1-(4-tert-Butylbenzyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamid; N-{3-[1-(4-tert-Butylphenyl)-3-isochinolin-3-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamid; N-[4-(1-Butyl-3-isochinolin-3-yl-1H-pyrazol-5-yl)benzoyl]tyrosinamid; N-{3-[1-(4-tert-Butylbenzyl)-3-chinolin-3-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamid; N-{3-[3-Isochinolin-3-yl-1-(4-propylphenyl)-1H-pyrazol-5-yl]benzoyl}tyrosinamid; N-{5-[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-{3-[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamid; N-{4-[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamid; N-{5-[1-(4-tert-Butylbenzyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-{3-[1-(4-tert-Butylbenzyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamid; N-{5-[1-(4-tert-Butylbenzyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-{5-[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl] pentanoyl}tyrosinamid; N-[3-(1-Butyl-3-isochinolin-3-yl-1H-pyrazol-5-yl)benzoyl]tyrosinamid; N-(4-{[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}butanoyl) tyrosinamid; N-({3-[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]propoxy} acetyl)}tyrosinamid; 4-[2-({3-[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]propyl}amino) ethyl]phenol; N-{3-[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]propyl}tyrosinamid; N-Acetyl-N-{3-[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]propyl}tyrosinamid; N-{3-[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]propyl}tyrosinamid; N-Acetyl-N-{3-[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]propyl}tyrosinamid; 3-[(4-{[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}butanoyl)amino]-4-(4-hydroxyphenyl)butanamid; N-(4-{[1-(4-tert-Butylphenyl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrazol -5-yl]amino}butanoyl)tyrosinamid; N-(3-{[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}propyl)tyrosinamid; N-Acetyl-N-(3-{[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}propyl)tyrosinamid; N-(4-{[1-(4-tert-Butylphenyl)-3-(1-oxidopyridin-4-yl)-1H-pyrazol-5-yl]amino}butanoyl)tyrosinamid; 4-{[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}-N-[2-(4-hydroxyphenyl)ethyl]butanamid; 4-{2-[(4-{[1-(4-tert-Butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}butyl) amino]ethyl}phenol; N-(4-{[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}butanoyl)tyrosinamid; N-(4-{[1-(4-tert-Butylphenyl)-3-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1H-pyrazol-5-yl]amino}butanoyl)tyrosinamid; (3R)-3-[(4-{[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}butanoyl)amino]-4-(4-hydroxyphenyl)butanamid; N-(3-{[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}propyl)tyrosinamid; N-Acetyl-N-(3-{[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}propyl)tyrosinamid; N-(4-{[1-(4-tert-Butylphenyl)-3-(1-oxidopyridin-3-yl)-1H-pyrazol-5-yl]amino}butanoyl)tyrosinamid; 4-{[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}-N-[2-(4-hydroxyphenyl)ethyl]butanamid; 4-{2-[(4-{[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino} butyl)amino]ethyl}phenol; N-(4-{[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]oxy}butanoyl)tyrosinamid; N-{5-[1-(4-tert-Butylphenyl)-3-chinolin-3-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-[5-(1-Butyl-3-chinolin-6-yl-1H-pyrazol-5-yl)pentanoyl]tyrosinamid; N-{5-[1-(4-tert-Butylphenyl)-3-chinolin-6-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-{5-[1-(4-tert-Butylbenzyl)-3-chinolin-6-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-[5-(1-Hexyl-3-pyrazin-2-yl-1H-pyrazol-5-yl)pentanoyl]tyrosinamid; N-{4-[1-Butyl-3-(2-furyl)-1H-pyrazol-5-yl]benzoyl}tyrosinamid; N-{5-[1-Butyl-3-(2-furyl)-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-{3-[3-(2-Furyl)-1-(4-isopropylphenyl)-1H-pyrazol-5-yl]propanoyl}tyrosinamid; N-[1-(Aminocarbonyl)-3-(4-hydroxyphenyl)propyl]-4-[3-(2-furyl)-1-(4-isopropylphenyl)-1 H-pyrazol-5-yl]benzamid; N-{5-[1-(4-tert-Butylphenyl)-3-(2-furyl)-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-(4-{1-(4-tert-Butylphenyl)-3-[3-(dimethylamino)phenyl]-1H-pyrazol-5-yl}benzoyl)tyrosinamid; N-(4-{3-[3-(Dimethylamino)phenyl]-1-pyridin-2-yl-1H-pyrazol-5-yl}benzoyl)tyrosinamid; N-(5-{1-Butyl-3-[3-(dimethylamino)phenyl]-1H-pyrazol-5-yl}pentanoyl)tyrosinamid; N-(5-{1-(4-tert-Butylphenyl)-3-[3-(dimethylamino)phenyl]-1H-pyrazol-5-yl}pentanoyl)tyrosinamid; N-{6-[1-(4-Isopropylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-{6-[1-(4-tert-Butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}tyrosinamid; N-({5-[1-(4-Isopropylphenyl)-3-pyridin-2-yl-1H-pyrazot-5-yl]thien-2-yl}carbonyl)tyrosinamid; N-{6-[1-(4-tert-Butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-{6-[1-(4-tert-Butylphenyl)-3-isochinolin-3-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamid; N-{5-[1-(4-tert-Butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]pentanoyl}threonamid; oder ein optisches Isomer, Racemat oder Tautomer einer beliebigen Verbindung hiervon oder ein pharmazeutisch akzeptables Salz einer beliebigen Verindung hiervon.

The compound according to claim 28 to 44 wherein the compound is selected from the group consisting of: N-{5-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamide; N-{5-[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamide; N-{5-[1-(4-tert-butylphenyl)-5-pyridin-3-yl-1H-pyrazol-3-yl]pentanoyl}tyrosinamide; N-{5-[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamide; N-{5-[1-(4-tert-butylphenyl)-5-pyridin-4-yl-1H-pyrazol-3-yl]pentanoyl}tyrosinamide; N-{5-[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]pentanoyl}-N,N-dimethyltyrosinamide; N-(3-[1-(4-tert-butylphenyl)-5-pyridin-3-yl-1H-pyrazol-3-yl]propanoyl)tyrosinamide; N-(3-[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]propanoyl)tyrosinamide N-[4-(1-butyl-3-isoquinolin-3-yl-1H-pyrazol-5-yl)benzoyl]tyrosinamide; N-{5-[1-(4-isopropylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamide; N-{6-[1-(4-isopropylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}tyrosinamide N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}-3-hydroxyphenylalaninamide; N-[1-(aminocarbonyl)-3-(4-hydroxyphenyl)propyl]-5-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]pentanamide; N-[5-(1-butyl-3-isoquinolin-3-yl-1H-pyrazol-5-yl)pentanoyl]tyrosinamide; N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}serinamide; N-{6-[1-(4-iso-propylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}serinamide; N-{6-[1-(4-iso-propylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}threonamide; N-{5-[1-(4-isopropylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamide; 6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]-N-[2-(4-hydroxyphenyl)ethyl]hexanamide; N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}tyrosinamide; N-{5-[1-(4-tert-butylphenyl)-3-isoquinolin-3-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamide; N-{6-[1-(4-tert-butylphenyl)-3-isoquinolin-3-yl-1H-pyrazol-5-yl]hexanoyl}tyrosinamide; N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}-N-methyltyrosinamide; N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}-4-(hydroxymethyl)phenylalaninamide; 4-amino-N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}phenylalaninamide; 4-(acetylamino)-N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}phenylalaninamide; 4-(aminocarbonyl)-N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}phenylalaninamide; N-butyl-N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}tyrosinamide; N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}threonamide; N-[2-amino-1-(4-hydroxyphenyl)-2-oxoethyl]-6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanamide; N-({5-[1-(4-isopropylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]-thien-2-yl}carbonyl)tyrosinamide; N-[2-amino-1-(4-hydroxyphenyl)-2-oxoethyl]-4-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]benzamide; 4-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]-N-[2-(4-hydroxyphenyl)ethyl]benzamide; N-{3-[1-(4-tert-butylbenzyl)-3-isoquinolin-3-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamide; N-{5-[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamide; N-{3-[1-(4-tert-butylbenzyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamide; N-{3-[1-(4-tert-butylphenyl)-3-isoquinolin-3-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamide; N-[4-(1-butyl-3-isoquinolin-3-yl-1H-pyrazol-5-yl)benzoyl]tyrosinamide; N-{3-[1-(4-tert-butylbenzyl)-3-quinolin-3-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamide; N-{3-[3-isoquinolin-3-yl-1-(4-propylphenyl)-1H-pyrazol-5-yl]benzoyl}tyrosinamide; N-{5-[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-1]pentanoyl}tyrosinamide; N-{3-[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamide; N-{4-[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamide; N-{5-[1-(4-tert-butylbenzyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamide; N-{3-[1-(4-tert-butylbenzyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]benzoyl}tyrosinamide; N-{5-[1-(4-tert-butylbenzyl)-3-pyridin-3-yl-1H-pyrazol-5-1]pentanoyl}tyrosinamide; N-{5-[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamide; N-[3-(1-butyl-3-isoquinolin-3-yl-1H-pyrazol-5-yl)benzoyl]tyrosinamide; N-(4-{[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino }butanoyl)tyrosinamide; N-({3-[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]propoxy}acetyl)}tyrosinamide; 4-[2-({3-[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]propyl}amino)ethyl]phenol; N-{3-[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]propyl}tyrosinamide; N-acetyl-N-{3-[1-(4-tert-butylphenyl)-3-pyridin -4-yl-1H-pyrazol-5-yl]propyl}tyrosinamide; N-{3-[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]propyl}tyrosinamide; N-acetyl-N- {3-[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]propyl}tyrosinamide; 3-[(4-{[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}butanoyl)amino]-4-(4-hydroxyphenyl)butanamide; N-(4-{[1-(4-tert-butylphenyl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrazol-5-yl]amino}butanoyl)tyrosinamide; N-(3-{[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}propyl)tyrosinamide; N-acetyl-N-(3-{[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}propyl)tyrosinamide; N-(4-{[1-(4-tert-butylphenyl)-3-(1-oxidopyridin-4-yl)-1H-pyrazol-5-yl]amino}butanoyl)tyrosinamide; 4-{[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl)amino}-N-[2-(4-hydroxyphenyl)ethyl]butanamide; 4-{2-[(4-{[1-(4-tert-butylphenyl)-3-pyridin-4-yl-1H-pyrazol-5-yl]amino}butyl)amino]ethyl}phenol; N-(4-{[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}butanoyl)tyrosinamide; N-(4-{[1-(4-tert-butylphenyl)-3-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1H-pyrazol-5-yl]amino}butanoyl)tyrosinamide; (3R)-3-[(4-{[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}butanoyl)amino]-4-(4-hydroxyphenyl)butanamide, N-(3-{[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}propyl)tyrosinamide; N-acetyl-N-(3-{[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}propyl)tyrosinamide; N-(4-{[1-(4-tert-butylphenyl)-3-(1-oxidopyridin-3-yl)-1H-pyrazol-5-yl]amino}butanoyl)tyrosinamide; 4-{[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}-N-[2-(4-hydroxyphenyl)ethyl]butanamide; 4-{2-[(4-{[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]amino}butyl)amino]ethyl}phenol; N-(4-{[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]oxy}butanoyl)tyrosinamide; N-{5-[1-(4-tert-butylphenyl)-3-quinolin-3-yl-1H-pyrazol-5-yl]pentanoyl} tyrosinamide; N-[5-(1-butyl-3-quinolin-6-yl-1H-pyrazol-5-yl)pentanoyl]tyrosinamide; N-{5-[1-(4-tert-butylphenyl)-3-quinolin-6-yl-1H-pyrazol-5-yl]pentanoyl} tyrosinamide; N-{5-[1-(4-tert-butylbenzyl)-3-quinolin-6-yl-1H-pyrazol-5-yl]pentanoyl} tyrosinamide; N-[5-(1-hexyl-3-pyrazin-2-yl-1H-pyrazol-5-yl)pentanoyl]tyrosinamide; N-{4-[1-butyl-3-(2-furyl)-1H-pyrazol-5-yl]benzoyl}tyrosinamide; N-{5-[1-butyl-3-(2-furyl)-1H-pyrazol-5-yl]pentanoyl}tyrosinamide; N-{3-[3-(2-furyl)-1-(4-isopropylphenyl)-1H-pyrazol-5-yl]propanoyl}tyrosinamide; N-[1-(aminocarbonyl)-3-(4-hydroxyphenyl)propyl]-4-[3-(2-furyl)-1-(4-isopropylphenyl)-1H-pyrazol-5-yl]benzamide; N-{5-[1-(4-tert-butylphenyl)-3-(2-furyl)-1H-pyrazol-5-yl]pentanoyl}tyrosinamide; N-(4-{1-(4-tert-butylphenyl)-3-[3-(dimethylamino)phenyl]-1H-pyrazol-5-yl}benzoyl)tyrosinamide; N-(4-{3-[3-(dimethylamino)phenyl]-1-pyridin-2-yl-1H-pyrazol-5-yl}benzoyl)tyrosinamide; N-(5-{1-butyl-3-[3-(dimethylamino)phenyl]-1H-pyrazol-5-yl}pentanoyl) Tyrosinamide; N-(5-{1-(4-tert-butylphenyl)-3-[3-(dimethylamino)phenyl]-1H-pyrazol-5-yl}pentanoyl)tyrosinamide; N-{6-[1-(4-isopropylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamide; N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]hexanoyl}-tyrosinamide; N-({5-[1-(4-isopropylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]thien-2-yl}carbonyl)tyrosinamide; N-{6-[1-(4-tert-butylphenyl)-3-pyridin-2-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamide; N-{6-[1-(4-tert-butylphenyl)-3-isoquinolin-3-yl-1H-pyrazol-5-yl]pentanoyl}tyrosinamide; N-{5-[1-(4-tert-butylphenyl)-3-pyridin-3-yl-1H-pyrazol-5-yl]pentanoyl}threonamide; or an optical isomer, racemate or tautomer of any one thereof or a pharmaceutically acceptable salt of any one thereof.