Threonin

Threonin

Threonine

Threonin

Theonine

L-Threonin

L-threonine

An der Position 3 ist es über die Aminosäure Threonin glykosyliert.

It is glycosylated at position 3 by the amino acid trieonine.

*ATP6V0B*ATP6V0C*ATP6V1E*ATP6V1F*ATP6V1G1==== Lysosom ====*CTSD, baut in Hepatozyten Insulin ab*Cystatin B, schützt vermutlich die Zelle vor undichten Lysosomen*LAMP1*Mannose-6-phosphat-Rezeptor*SGSH, Mutationen können das Sanfilippo-Syndrom erzeugen==== Proteasom ====*PSMB1*PSMB2*PSMB4*PSMB6*PSMA7*PSMB7*PSMD8*PSMD11*PSME2*UBA1*Ubiquitin B*UBE2I*UBE2D2*UBE2M*USP11==== Ribonuklease ====*RNH Ribonuklease-Hemmstoff==== Oxidase/Reduktase ====*TXN Thioreduktase=== Strukturelle Proteine ======= Zytoskelett ====*Actinin alpha 4*ACTG1 gamma-Aktin*ADD1*ANXA6*ARPC4 "Actin-related protein 2/3 complex"*Beta-Aktin*CAPZB*COL6A1*DNCL1 Cytoplasmic Dynein*EZR Ezrin (verankert Aktin in der Zellmembran)*KIFC3 kinesin*Moesin*MYH9 "Myosin, heavy chain 9"*RHOA vermutlich am Zellzyklus beteiligt*SEPT1 homolog zu CDC10 in "S. cerevesiae"*SEPT2*SLC9A3R2 bindet SLC9A3 an das Zytoskelett*TAGLN*TAGLN2*TMSB10 Thymosin ?10*TUBB Tubulin, beta-Polypeptid*TUBB4*WDR1==== Organellsynthese ====Eine spezielle Form der Zellsignalisierung*BLOC1S1*AP2M1*ANXA2*ANXA6*ANXA7*AP1B1 Endozytose*CLTA Clathrin A (Vesikel)*CLTB Clathrin B (Vesikel)*GP2 enzymatische sekretorische Granula (v. a. im Pankreas)*KDELR1 KDEL-Rezeptor bindet ER-Proteine==== Mitochondrium ====*MTX1=== Zelloberfläche ===*AP2S1*CD81*GPAA1*LGALS9*MGAT1*VAMP3==== Zelladhäsion ====*ADAM15*Beta-catenin*CNTN1 Contactin*Delta-catenin==== Kanäle und Transporter ====*ABCG2 früher BCRP1 xenobiotic transporter, gering exprimiert*CALM1 Calmodulin bindet Calciumionen*CALM2 Calmodulin bindet Calciumionen*HPCAL1 bindet Calciumionen; exprimiert v. a. in der Retina*GRIK5*MFSD10 aka TETRAN or tetracycline transporter-like protein*TFRC Transferrinrezeptor*FOLR1 Folatrezeptor*SLC25A11 mitochondrialer Oxoglutarat/Malat-Transporter==== Rezeptoren ====*ACVRL1 TGF-?-Rezeptorfamilie (Morbus Osler)*CD23A FCER2 low affinity IgE receptor (Lectin)*GRM4 metabotoper Glutamatrezeptor*JAG1 NOTCH2-Rezeptor "assoziiert mit dem Alagille-Syndrom"*MC2R Melanocortin-2-Rezeptor (ähnlich dem ACTH-Rezeptor)*SSTR5 Somatostatin-Rezeptor; neigt dazu, andere Hormone hemmen==== HLA, Immunoglobuline und Zellerkennung ====*BAT1*BSG Basigin-Immunglobulin-Superfamilie, extrazelluläre Metalloproteinase*B2M ?2-Mikroglobulin*HLA-C*HLA-G*MIF Macrophagenmigration inhibierender Faktor*TAPBP=== Kinasen und Signaltransduktion ===*ADRBK1 mindert die Reaktion auf Epinephrin*AGPAT1 3-Phosphoglycerol-Acyltransferase*ARF1*ARF3*ARF4*ARF5*ARL2 RAS-Superfamilie*CSF1 Koloniestimulierender Faktor, gering exprimiert*CSK C-src tyrosine kinase*DCT Dopachrom-Tautomerase*EFNA3*FKBP1A*GDI1 GDI-Dissoziationsinhibitor (Rab-Familie)*GNAS1 ubiquitär exprimiert, aber differentielles Imprinting*GNAI2*HAX1 assoziiert mit Tyrosinkinasen*ILK Integrin linked kinase*MAPKAPK2*MAP2K2*MAP3K11*PITPNM Phosphatidylinositol-Transfer-Proteine*RAC1 Rho-GTPase*RAP1B GTPase, beteiligt an der Zelladhäsion*RAGA Ras-verwandtes GTP-bindendes Protein*STK19*STK24 Serin/Threonin-Kinase*STK25*YWHAB Tyrosin-3-Monooxygenase/Tryptophan-5-Monooxygenase aktivierendes Protein, ?-Polypeptid*YWHAH Tyrosin-3-Monooxygenase/Tryptophan-5-Monooxygenase aktivierendes Protein, h-Polypeptid*YWHAQ Tyrosin-3-Monooxygenase/Tryptophan-5-Monooxygenase aktivierendes Protein, ?-Polypeptid*YWHAZ Tyrosin-3-Monooxygenase/Tryptophan-5-Monooxygenase aktivierendes Protein, ?-Polypeptid==== Wachstumsfaktoren ====*AIF1*HDGF Hepatom-abgeleiteter Wachstumsfaktor (transloziert zum Zellkern)*HGS*LTBP4*VEGFB*ZFP36L1==== Gewebe-Nekrose-Faktoren ====*CD40 früher TNFRSF5==== Caseinkinasen ====*CSNK1E*CSNK2B=== Verschiedenes ===*ALAS1 ?-Aminolävulinatsynthase Typ 1 (Typ 2 ist erythroid und mit Porphyrie assoziiert)*ARHGEF2 Guanin-Nukleotid-Austauschfaktor*ARMET Mesencephalere Astrozyten-abgeleiteter neurotropher Faktor*AES Amino-terminal Enhancer of Split*BECN1 beteiligt an der Autophagie*BUD31 früher Maternal G10 transcript*Creatine kinase CKB (ATP-Reservoir)*Cytidine deaminase*CPNE1*ENSA (gene)*FTH1 Ferritin schwere Kette*GDI2 rab/ras vesikulärer Transport*GUK1 Guanylatkinase*HPRT Hypoxanthine-guanine phosphoribosyltransferase*IFITM1 "Induced by interferon, transmembrane protein"*JTB (gene) Jumping translocation breakpoint*MMPL2*NME2 (früher NM23B) Nukleosid-Diphosphat-Kinase*NONO*P4HB*PRDX1 Peroxiredoxin (reduziert Peroxide)*PTMA Prothymosin*RPA2 Bindet DNA während der Replikation und streckt sie*SULT1A3 Sulfotransferase*SYNGR2 Synaptogyrin (nimmt möglicherweise an der Vesikeltranslokation teil)*Tetratricopeptide, TTC1 "small glutamine rich tetratricopeptide"==== Offene Leseraster ====*C11Orf13*C14orf2*C21orf33==== Begrenzt auf Spermien oder Hoden ====*SPAG7*SRM Spermidinsynthase*TEGT Bax-Inhibitor 1*DAZAP2 Gendeletion im Fall von Azoospermie*MEA1 Male Enhanced Antigen 1== Einzelnachweise ==

====Organelle Synthesis===="A specialized form of cell signaling"*BLOC1S1*BLOC1S2NM_173809*BLOC1S3NM_212550*BLOC1S4NM_018366*BLOC1S6NM_012388*AP1G1 NM_001128*AP1M1 NM_032493*AP2A1 NM_014203*AP2A2 NM_012305*AP2M1*AP2S1 NM_004069*AP3B1 NM_003664*AP3D1 NM_003938*AP3M1 NM_012095*AP3S1 NM_001284*AP3S2 NM_005829*AP4B1 NM_006594*AP5M1 NM_018229*ANXA6 Annexin 6*ANXA7 Annexin 7*AP1B1 Coated vessicles*CLTA Clathrin A (vessicles)*CLTB Clathrin B (vessicles)*CLTC====Mitochondrion====*MTX2===Surface===*AP2S1*CD81*GPAA1*LGALS9*MGAT2*MGAT4B*VAMP3====Cell Adhesion====*CTNNA1 NM_001903*CTNNB1*CTNNBIP1 NM_020248*CTNNBL1 NM_030877*CTNND1 NM_001085458 delta catenin====Channels and Transporters====*ABCB10 NM_012089*ABCB7 NM_004299*ABCD3 NM_002857*ABCE1 NM_002939*ABCF1 NM_001090*ABCF2 NM_005692*ABCF3 NM_018358*CALM1 Calmodulin grasps calcium ions*MFSD11 NM_024311 similar to MSFD10 aka TETRAN or tetracycline transporter-like protein*MFSD12 NM_174983*MFSD3 NM_138431*MFSD5 NM_032889*SLC15A4 NM_145648*SLC20A1 NM_005415*SLC25A11 mitochondrial oxoglutarate/malate carrier*SLC25A26 NM_173471*SLC25A28 NM_031212*SLC25A3 NM_002635*SLC25A32 NM_030780*SLC25A38 NM_017875*SLC25A39 NM_016016*SLC25A44 NM_014655*SLC25A46 NM_138773*SLC25A5 NM_001152*SLC27A4 NM_005094*SLC30A1 NM_021194*SLC30A5 NM_022902*SLC30A9 NM_006345*SLC35A2 NM_005660*SLC35A4 NM_080670*SLC35B1 NM_005827*SLC35B2 NM_178148*SLC35C2 NM_015945*SLC35E1 NM_024881*SLC35E3 NM_018656*SLC35F5 NM_025181*SLC38A2 NM_018976*SLC39A1 NM_014437*SLC39A3 NM_144564*SLC39A7 NM_006979*SLC41A3 NM_017836*SLC46A3 NM_181785*SLC48A1 NM_017842====Receptors====*ACVR1 NM_001105 similar to ACVRL1 TGF Beta receptor family "Rendu-Osler-Weber syndrome"*ACVR1B NM_004302*CD23 FCER2 low affinity IgE receptor (lectin)====HLA/Immunoglobulin/Cell recognition====*BAT1 aka DDX39B which is involved in RNA splicing*BSG Basigin Immunoglobulin Superfamily, extracelluar metalloproteinase*MIF macrophage migration inhibitory factor*TAPBP===Kinases/Signalling===*ADRBK1 can downregulate response to epinephrine*AGPAT1 acyl 3 phosphoglycerol acyl transferase*ARF1*ARF3*ARF4*ARF5*ARL2 RAS Superfamily*CSF1 Colony stimulating factor "not highly expressed constitutively at 5-12"*CSK C-src tyrosine kinase*DCT dopachrome tautomerase*EFNA3*FKBP1A*GDI1 GDP Dissociation inhibitor (Rab family)*GNAS1 ubiquitously expressed, but differentially imprinted*GNAI2*HAX1 associated with tyrosine kinases*ILK Integrin linked kinase*MAPKAPK2*MAP2K2*MAP3K11*PITPNM Phosphatidylinositol transfer protein*RAC1 Ro GTPase involved with many signaling pathways*RAP1B GTPase involved with cell adhesion*RAGA Ras-related GTP Binding*STK19*STK24 Serine/Threonine Kinase*STK25*YWHAB Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide*YWHAH Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, h polypeptide*YWHAQ Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide*YWHAZ Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide====Growth Factors====*AIF1*HDGF Hepatoma derived growth factor "(translocates to nucleus)"*HGS*LTBP4*VEGFB*ZFP36L1====Tissue Necrosis Factor====*CD40 formerly TNFRSF5====Casein Kinase====*CSNK1E*CSNK2B===Miscellaneous===*ALAS1 Aminolevulinic Acid Synthase type 1 (type 2 is erythroid and associated with porphyria)*ARHGEF2 Rho guanine nucleotide exchange factor*ARMET Mesencephalic astrocyte-derived neurotrophic factor*AES amino terminal enhancer of split*BECN1 involved in autophagy and partners with PI3K*BUD31 formerly Maternal G10 transcript*Creatine kinase CKB (ATP reservoir)*Cytidine deaminase "questionable: not present in very high levels at all"*CPNE1*ENSA (gene)*FTH1 Heavy chain of Ferritin*GDI2 rab/ras vessicular trafficking*GUK1 Guanylate kinase transfers phosphate from ATP to GMP*HPRT Hypoxanthine-guanine phosphoribosyltransferase*IFITM1 "Induced by interferon, transmembrane protein"*JTB (gene) Jumping translocation breakpoint*MMPL2*NME2 (formerly NM23B) Nucleoside diphosphate kinase*NONO*P4HB*PRDX1 peroxiredoxin (reduces peroxides)*PTMA Prothymosin*RPA2 Binds DNA during replication to keep it straightened out*SULT1A3 Sulfate conjugation "(note: SULT1C is cited in earlier literature as being ubiquitous but this may be an example of different tags being used to refer to a common area of 2 closely related genes.

Beispiele für Trägermolekül-affine Substanzen in der erfindungsgemäßen Ligandenverbindung sind aus folgenden Gruppen ausgewählt: Naphthalin- und Naphtylderivate: beispielsweise Benzophenonderivate: beispielsweise Phthal- und lsophthalimid-derivate und Phthal- und lsophthalsäurederivate: beispielsweise Chinolin- und Isochinolinderivate: beispielsweise Anthrachinonderivate: beispielsweise Anthracenderivate: beispielsweise Phenanthren-und Phenanthrolinderivate: beispielsweise Benzylidenderivate: beispielsweise Di- und Biphenylderivate: beispielsweise Tryptophan- und Indolderivate: beispielsweise Indanderivate: beispielsweise Hippursäurederivate: beispielsweise Imidazol- und Benzimidazolderivate: beispielsweise Chinoxalinderivate: beispielsweise Pyridinderivate: beispielsweise Cumarinderivate: beispielsweise Flavon- und Flavonoidderivate: beispielsweise Pyrimidinderivate: beispielsweise Piperidinderivate: beispielsweise Sarcosinderivate: beispielsweise Oxazol-, Oxadiazol- und lsooxazolderivate: beispielsweise Pyrazol-, Tri- und Tetraazolderivate: beispielsweise Thiazol- und Benzothiazolderivate: beispielsweise Triazinderivate: beispielsweise Morphotinderivate: beispielsweise Chromenderivate: beispielsweise Pyrrol- und Di-, Tri-, und Tetrapyrrolderivate und deren metallorganischen Verbindungen, d.h. Porphyrine und Protoporphyrine: beispielsweise Tri-, Tetra-, Pentasubstituerte Ethan- bzw. Propansäurederivate: beispielsweise Stilbenderivate: beispielsweise Mit Halogenatomen (C1, Br oder I) 2-5-fach substituierten aromatischen Verbindungen: beispielsweise 1-(4-BENZOYLPHENYL)-3-(2,4-DICHLOROPHENYL)HARNSTOFF, N,N'-(4-(ALPHA-CYANO-2,4-DICHLOROSTYRYL)-1,2-PHENYLEN)-BISESSIGSÄUREAMID, 1-(2-BENZOYL-4-CHLOROPHENYL)-3-(2,5-DICHLOROPHENYL)HARNSTOFF, 1-(4-BENZOYLPHENYL)-3-(2,5-DICHLOROPHENYL)HARNSTOFF, 3',4'-DICHLOROPHTHALANILINSÄURE, 1-(2-BENZOYL-4-CHLOROPHENYL)-3-(2,6-DICHLOROPHENYL)HARNSTOFF, 1-(2-BENZOYL)-4-CHLOROPHENYL)-3-(2,3-DICHLOROPHENYL)HARNSTOFF, 1-(2-CARBOXYPHENYL)-3-(2,3-DICHLOROPHENYL)HARNSTOFF, 1-(2-CARBOXYPHENYL)-3-(3,4-DICHLOROPHENYL)HARNSTOFF, 2-[(2-CARBOXY-4,6-DICHLOROPHENYL)THIO]-3,5-DICHLOROBENZOESÄURE, 4-[2-(2,4-DICHLOROPHENOXY)ANILINO]-4-OXOBUT-2-ENOIC ACID, 4-[2-(2,4-DICHLOROPHENOXY)ANILINO]-4-OXOBUTANSÄURE, N-BENZOYL-N'-[2-(2,4-DICHLOROPHENOXY)PHENYL]THIOHARNSTOFF, 3-[(3,5-DICHLOROANILINO)CARBONYL]PYRAZIN-2-CARBONSÄURE, N1-(4-FLUOROPHENYL)-2-[[(3,4-DICHLOROANILINO)CARBOTHIOYL]AMINO]BENZAMID, N-[2-(2,4-DICHLOROPHENOXY)PHENYL]-N'-(2,6-DIFLUOROBENZOYL)HARNSTOFF, N-(2-CHLORO-6-FLUOROBENZOYL)-N'-[2-(2,4-DICHLOROPHENOXY)PHENYL]HARNSTOFF, N1-[2-[5-(3,4-DICHLOROPHENYL)-1,3,4-OXADIAZOL-2-YL]PHENYL]-3-METHYLBENZAMID, ETHYL 2-[(5-CHLORO-3-PYRIDYL)OXY]-5-[[(3,4-DICHLOROANILINO)CARBONYL]AMINO]BENZOESÄURE, N-[2-(2,4-DICHLOROPHENOXY)BENZOYL]-N'-(2,4-DIFLUOROPHENYL)HARNSTOFF, N-[2-(2,4-DICHLOROPHENOXY)BENZOYL]-N'-(3,5-DICHLOROPHENYL)HARNSTOFF, 3-[[(2,5-DICHLOROANILINO)CARBOTHIOYL]AMINO]PROPANSÄURE, N1-(4-[[(3,4-DICHLOROANILINO)CARBOTHIOYL]AMINO]PHENYL)-2-HYDROXYBENZAMID, N1-(4-[[(2,3-DICHLOROANILINO)CARBOTHIOYL]AMINO]PHENYL)-2-HYDROXYBENZAMID, N1-(3-[[(3,4-DICHLOROANILINO)CARBOTHIOYL]AMINO]PHENYL)-2-HYDROXYBENZAMID, 1-(1-(3,4-DICHLOROBENZYL))-3-(2-METHOXYCARBONYLPHENYL)UREIDO-2-PYRIDON, 1-(1-(3,4-DICHLOROBENZYL))-3-(3-ISOPROPOXYPHENYL)UREIDO-2-PYRIDON, BIS-(4-METHYLPHENYLAMINO)MALONAMID-2-(2,4-DICHLOROBENZYL OXIM)-METHYLEN, 4-(3-(3-CHLOROPHENYL)UREIDO)BENZOESÄURE (3,4-DICHLOROBENZYLIDEN)HYDRAZID, 3-(N-(3,4-DICHLOROPHENYL)CARBAMOYL)-5-NORBORNEN-2-CARBONSÄURE, 2-CARBOXYMETHYLTHIO-2',4'-DICHLORO-2-PHENYLESSIGSÄUREANILID, O-(2,4-DICHLOROBENZYL)-N-[1-PHENYL-1,2,4-TRIAZOL-3-OXYACETYL]FORMADOXIM, 3,3-DICHLORO-2-(4-CHLORO-BENZOYLAMINO)-ACRYLLSÄURE, 2-[[2-(3,5-DICHLOROANILINO)-2-OXOETHYL]THIO]NICOTINSÄURE, 1-[[(2,3-DICHLOROANILlNO)CARBOTHIOYL]AMINO]ETHYLPHOSPHONSÄURE, 2-[[2-(2,4-DICHLORO-5-ISOPROPOXYANILINO)-2-OXOETHYL]SULFANYL]ESS1GSÄURE, 2-([2-[5-(BENZYLOXY)-2,4-DICHLOROANILINO]-2-OXOETHYL]SULFANYL)ESSIGSÄURE, 2-([2-[2,4-DICHLORO-5-(2-PROPYNYLOXY)ANILINO]-2-OXOETHYL]SULFANYL)ESSIGSÄURE, 2,4-DICHLORO-N-[3-[(2,4-DICHLOROBENZOYL)AMINO]-3-OXOPROPANOYL]BENZOLCARBOXAMID, FMOC-(R)-3-AMINO-4-(3,4-DICHLORO-PHENYL)-BUTTERSÄURE, FMOC-2,4-DICHLORO-L-PHENYLALANIN, 1-(2-BENZOYL-4-CHLOROPHENYL)-3-(2,4,5-TRICHLOROPHENYL)HARNSTOFF, 3-(3-(2,4,5-TRlCHLOROPHENYL)UREIDO)BENZOESÄURE, N1-(4-FLUOROPHENYL)-2-(BENZOYLAMINO)-3,5-DIBROMOBENZAMID, 2,3,5-TRIIODOBENZOESÄURE, IOPHENOXINSÄURE; Farbstoffe aus der Klasse der Azofarbstoffe: beispielsweise P-PHENYLAZOMALEANILIC ACID, 2-(2-PYRIDYLAZO)CHROMOTROPSÄURE, 2,2'-AZOXYDIBENZOESÄURE, 4-(1,8-DIHYDROXY-3,6-DISULFO-2-NAPHTHYLAZO)-SALICYLSÄURE, 3-(2-(2,5-DICHLOROPHENYLAZO)-5-(DIETHYLAMINO)-PHENYLCARBAMOYL)-PROPIONSÄURE, 1-(4-(METHYLTHIO)PHENYL)-3-(4-(PHENYLAZO)PHENYL)HARNSTOFF, 2-HO-5-(4'-HO-BIPHENYL-4-YLAZO)-BENZOESÄURE, PYRIDYL-2-AZOCHROMOTROPSÄURE, SULFONAZO III, BRILLIANT CROCEIN MOO (= ACID RED 73), TROPAEOLIN (=ACID ORANGE 6), CHICAGOBLAU 6B, BORDEAUX R, ERIOCHROMSCHWARZ, ACID RED 151, DISPERSE GELB 7, PONCEAU SS, DIMETHYLAMINO-1-NAPHTHYLAZO-4-METHOXYBENZOLSULFONSÄURE, SUDAN II SÄURE ROT 88, MORDANT BRAUN 1, TRYPANBLAU (=DIREKT BLAU 14), EVANS BLAU, SÄURE ORANGE 8, SUDAN IV, MORDANT BRAUN 33, DIREKTGELB 50, HABA (= 2-(4'-HYDROXYBENZOLAZO)-BENZOESÄURE), CONGO ROT, 8-HYDROXY-7-(4-SULFOLNAPHTHYLAZA)-5-CHINOLINSÄURE, SULFANILAZOCHROMOTROP, NAPHTHOLSCHWARZ, NITROROT, XYLIDINE PONCEAU, ORANGE G, MORDANT GELB 10, BENZOPURPURIN 4B, CROCEIN ORANGE G, METANILGELB, DIREKT ROT 81; Farbstoffe aus der Klasse der Anthrachinone: beispielsweise ALIZARIN COMPLEXON (=N-(3,4-DIHYDROXY-2-ANTHRACHINONYLMETHYLIMINODIESSIGSÄURE), ALIZARIN, REMAZOL BRILLIANT BLAU R, ALIZARIN GELB GG, ALIZARIN ROT S, ALIZARIN BLUE BLACK B, NUCLEAR FAST REU; Farbstoffe aus der Klasse der Phtaleine und Sulfophtaleine: beispielsweise BROMKRESOLGRÜN, TETRAIODOPHENOLPHTHALEIN, TETRABROMOPHENOLSULFONPHTHALEIN, BROMCRESOLLIA, THYMOLBLAU, BROMTHYMOLBLAU, KRESOLROT, JODPHENOLBLAU (=TETRAIODOPHENOLSULFONPHTHALEIN), BROMCHLORPHENOLBLAU, TETRABROMPHENOLBLAU, BROMPYROGALLOROT, COOMASSIE BRILLIANTBLAU R250, CHLORPHENOL RED XYLENOLBLAU, SÄURE VIOLET 17; Di-, Tri-, Tetra-, Penta- und Hexapeptide, die durch Z (= Benzyloxycarbonyl), BOC (N-tert.-Butoxycarbonyl), FMOC (N-9-Fluorenylmethoxycarbonyl), Ac (= Acetyl) bzw. CBZ (=Carbobenzyloxy) substituiert sein können: beispielsweise Z-TYR-TYR-OH, Z-VAL-ALA-OH, Z-ILE-ALA-OH, AC-ALA-ALA-ALA-ALA-OH, Z-VAL-PHE-OH, Z-MET-PHE-OH, DL-LEUCYL-GLYCYL-DL-PHENYLALANIN, Z-PRO-D-LEU-OH, CARBOBENZYLOXY-L-VALYLGLYCYLGLYCIN, Z-LEU-GLY-GLY-OH, Z-ALA-GLY-GLY-OH, Z-ALA-TRP-OH, CARBOBENZYLOXY-L-METHIONYL-L-TRYPTOPHAN, CARBOBENZYLOXY-L-PHENYLALANYL-L-TRYPTOPHANAMID, CARBOBENZYLOXY-L-ISOLEUCYL-L-PHENYLALANINAMID, Z-PHE-MET-OH, Z-VAL-MET-OH, Z-LEU-MET-OH, CARBOBENZYLOXY-L-NORVALYL-L-LEUCIN, H-GLY-LEU-GLY-LEU-OH, Z-ILE-ILE-OH, Z-PHE-ILE-OH, Z-NVA-NVA-OH, N-ALPHA-Z-L-ARGININ HYDROBROMID, N-FORMYL-MET-LEU-PHE, FMOC-ASN-OH, H-PHE-ARG-OH, ARG-ILE, H-PHE-TYR-OH, Z-PHE-TYR, Z-GLU-TYR-OH, TYR-LEU, H-GLU(TYR)-OH, Z-LEU-ALA-OH, Z-TYR-ALA-OH, Z-PHE-ALA-OH, Z-GLY-ALA-OH, Z-GLY-GLY-ALA-OH, H-TYR-PHE-OH, PHE-PHE-PHE, Z-GLU-PHE-OH, Z-GLY-PHE-OH, H-GLU-GLY-PHE-OH, Z-LEU-GLY-OH, H-PHE-ASP-OH, H-ARG-ASP-OH, Z-GLY-ASP-OH, TYR-GLU, H-ARG-GLU-OH, H-GLU-ASP-OH, GLU-GLU, H-GLU-GLU-GLU-OH, Z-ALA-PRO-OH, Z-PHE-PRO-OH, Z-PHE-GLY-OH, H-PHE-GLY-GLY-OH, TYR-GLY-GLY, Z-GLY-GLY-GLY-OH, Z-THR-PHE-OH, Z-TYR-THR-OH, Z-ORN(Z)-OH, Z-HIS-PHE-OH, H-PRO-VAL-ASP-OH, PYR-ASN-GLY-OH, Z-TRP-ALA-OH, H-LEU-TRP-LEU-OH, H-MET-TRP-OH, H-GLU-TRP-OH, H-ARG-TRP-OH, H-LYS-TRP-OH, AC-PHE-TRP-OH, H-TRP-TRP-OH, H-TRP-SER-OH, TRP-PHE, H-TRP-TYR-OH, H-TRP-LEU-OH, H-TRP-GLU-OH, H-ALA-PHE-GLY-OH, H-GLY-GLY-MET-OH, H-GLY-GLY-GLU-OH, ARG-LYS, H-LYS-GLU-OH, H-LYS-TYR-GLU-OH, H-LYS-GLU-GLY-OH, H-LYS-LYS-LYS-OH, Z-LEU-LEU-OH, Z-ALA-LEU-OH, Z-TYR-LEU-OH, Z-PHE-LEU-OH, Z-GLY-GLY-LEU-OH, H-DL-ALA-DL-LEU-GLY-OH, H-MET-PHE-GLY-OH, H-GLU-TYR-GLU-OH, H-MET-ARG-PHE-OH, H-PHE-ILE-OH, H-LEU-TRP-MET-OH, N-FORMYL-MET-PHE-MET, L-GLN-L-GLN-L-GLN, Z-ARG-OH HCL, H-ARG-ARG-OH ACOH, H-ALA-ARG-OH, Z-GLY-HIS-OH, N-ACETYL-5-BENZYLOXY-DL-TRYPTOPHAN, Z-GLY-TRP-OH, H-TRP-ILE-OH, LEU-ARG, Z-GLY-TYR-OH, CARBOBENZYLOXY-BETA-ALANYL-L-ALANIN, Z-GLY-GLY-SER-OH, MET-LEU-PHE, Z-GLY-GLY-PHE-OH, CARBOBENZYLOXY-BETA-ALANYL-L-PHENYLALANIN, Z-GLY-GLY-NLE-OH; H-ARG-ASP-OH, Z-ALA-GLU-OH, Z-GLY-GLY-PRO-OH, Z-ILE-GLY-GLY-OH, Z-BETA-ALA-GLY-GLY-OH, H-GLU-LYS-OH, Z-GLY-GLY-MET-OH, Z-GLY-GLY-ILE-OH, N-CBZ-BETA-ALA-BETA-ALA, N-ACETYL-MET-LEU-PHE, GLU-VAL-PHE, S-DECYLGLUTATHION, S-PROPYLGLUTATHION, S-BUTYLGLUTATHION, S-HEXYLGLUTATHION, S-OCTYLGLUTATHION, S-(P-CHLOROPHENACYL)GLUTATHION, S-(P-AZIDOPHENYLACYL)-GLUTATHION, Z-PRO-LEU-GLY-OH, Z-PRO-LEU-GLY-NH2, N-FORMYL-NLE-LEU-PHE, GLY-PHE-ARG, BOC-PHE-PHE-GLY-OH, H-ASP-GLU-OH, H-TYR-TYR-PHE-OH, H-GAMMA-GLU-TRP-OH, GLUTATHIONSULFONSÄURE, H-ASP-GLN-OH, H-ARG-GLY-ASP-OH, H-LYS-LYS-OH 2 HCL, ARG-SER-ARG, Z-ALA-PRO-TYR-OH, AC-PHE-TYR-OH, H-TYR-TYR-OH; H-ASP-PHE-OH, N-CARBOBENZOXYGLYCYL-DL-PHENYLALANIN, H-GLU-TYR-OH, S-ETHYLGLUTATHION, H-ALA-ALA-ALA-ALA-OH, H-ARG-LYS-OH, Z-VAL-LEU-OH, H-ARG-ARG-OH, N-FORMYL-NLE-LEU-PHE-OH, H-TYR-GLY-GLY-PHE-OH, ALA-GLY-SER-GLU, VAL-GLY-SER-GLU, H-ARG-GLY-ASP-ALA-OH, H-ARG-GLY-ASP-CYS-OH, H-ARG-GLY-ASP-SER-OH, ARG-GLY-GLU-SER, H-ARG-GLY-ASP-VAL-OH, H-GLY-ARG-GLY-ASP-OH, H-LYS-GLY-ASP-SER-OH, AC-ASP-GLU-OH, H-GLY-GLY-TYR-ARG-OH, AC-SER-ASP-LYS-PRO-OH, Z-GLY-GLY-GLY-GLY-GLY-OH, H-ALA-GLY-GLY-GLY-GLY-OH, H-LYS-TYR-LYS-OH, H-D-TYR-TRP-GLY-OH, BOC-ALA-GLY-GLY-OH, GLU-ALA-GLU, LYS-TYR-LYS, SER-ASP-GLY-ARG, AC-TYR-VAL-GLY, BZ-GLY-ALA-PRO, Z-GLY-PRO-LEU, Z-GLY-PRO-LEU GLY, Z-TYR-GLU-OH, H-ALA-ALA-TYR-ALA-ALA-OH, SUC-ALA-ALA-ALA-4M-BETANA [?], H-ARG-TRP-OH SALZ, H-ARG-TYR-OH SALZ, H-ASP-ARG-BETA-NA, H-LYS-PHE-TYR-OH, Z-PRO-LEU-GLY-NHOH, H-GLY-GLY-ARG-ALA-OH, H-GLY-GLY-GLU-ALA-OH, H-GLY-GLY-GLY-GLY-GLY-OH, GLY-GLY-GLY-GLY-GLY-GLY, H-ILE-ARG-OH, H-LYS-THR-TYR-OH, H-LYS-TYR-SER-OH, H-MET-ARG-OH, PHE-GLY-GLY-PHE, H-PHE-TRP-OH, H-TYR-LYS-OH, H-TYR-TRP-OH, VAL-ALA-ALA-PHE, CARBOBENZYLOXYALANYLMETHIONIN, CARBOBENZYLOXYGLYCYLGLYCYLSARCOSIN, CARBOBENZYLOXYISOLEUCYLMETHIONIN, CARBOBENZYLOXYGLYCYLLEUCYLGLYCIN BENZYL ESTER, CARBOBENZYLOXYTRYPTOPHAN BETA-NAPHTHYLAMID, N-BENZYLGLYCYLGLYCYLPHENYLALANIN, CARBOBENZYLOXYNORVALYLTRYPTOPHANAMID, CARBOBENZYLOXYPHENYLALANYLGLYCYLGLYCIN METHYL ESTER, GLU-ALA-GLU-ASN, GLY-ARG-GLY-ASP, GLY-PRO-GLY-GLY, H-MET-GLY-MET-MET-OH, N-ACETYL-BETA-ASP-GLU, N-FORMYL-ALA-GLY-SER-GLU, SUC-ALA-ALA-VAL-OH, BOC-ALA-GLY-GLY-GLY-OH, ORN ORN-ORN, PHE-GLY-PHE-GLY, PRO-THR-PRO-SER, VAL-GLY-ASP-GLU, VAL-THR-LYS-GLY, AC-MET-ALA-SER-OH, AC-PRO-LEU-GLY-OH, BOC-PHE-GLY-OH, Z-TYR-LEU-NH2, H-VAL-VAL-GLY-OH, AC-D-PHE-TYR-OH, Z-HIS-TYR-OH, CARBOBENZYLOXY-L-TRYPTOPHYL-L-PHENYLALANINAMID, CARBOBENZYLOXY-L-TYROSYL-L-ALANINAMID, CARBOBENZYLOXY-L-SERYL-L-PHENYLALANIN, CARBOBENZYLOXY-L-PHENYLALANYLGLYCYLGLYCINAMID, ARBOBENZYLOXYGLYCYLGLYCYL-L-THREONIN, H-GLY-GLY-GLY-GLY-ALA-OH, Z-DL-GLU-OH, Z-HIS-GLY-OH, CARBOBENZYLOXY-L-HISTIDYLGLYCYLGLYCIN, CARBOBENZYLOXY-L-TYROSYL-L-THREONINAMID, Z-TRP-GLY-OH, Z-TYR-VAL-OH, CARBOBENZYLOXY-L-HISTIDYL-L-TYROSINAMID, CARBOBENZYLOXY-S-BENZYL-L-CYSTEINYL-L-LEUCINAMID, N,N'-BIS(CARBOBENZYLOXY)-L-LYSYLGLYCINAMID, CARBOBENZYLOXY-L-TRYPTOPHYL-L-LEUCINAMID, Z-TYR-PHE-OH, CARBOBENZYLOXY-L-ISOLEUCYL-L-TYROSINAMID, Z-TRP-PHE-OH, CARBOBENZYLOXY-L-TRYPTOPHYLGLYCYLGLYCIN METHYL ESTER, CARBOBENZYLOXY-L-SERYL-L-TYROSIN, CARBOBENZYLOXY-L-TYROSYLGLYCIN, Z-GLY-D-TRP-OH, H-TYR-TYR-OH, BOC-D-GLN(XAN)-OH, H-ASP-ASP-ASP-OH, H-ASP-ASP-ASP-ASP-OH, H-ASP-ALA-SER-VAL-OH, H-MET-LEU-PHE-OH ACOH, H-D-TYR-GLU-GLY-OH, H-D-TYR-PHE-GLY-OH ACOH, H-TYR-THR-OH, H-D-TYR-TRP-GLY-OH ACOH, Z-ALA-TYR(BZL)-OH, Z-GLY-HIS-OH, Z-PHE-GLY-GLY-OH, GLYCYLGLYCYLGLYCYLGLYCYLALANIN, TRH-GLY, VAL-THR-CYS-GLY, H-ARG-GLU-OH, H-GLY-GLY-GLY-GLY-GLY-GLY-OH, H-TRP-PHE-OH, H-TYR-GLU-OH, H-ARG-TYR-OH, BOC-GLY-ASP-OH, BOC-PHE-GLY-GLY-OH, FMOC-ALA-ALA-OH, FMOC-ALA-GLY-OH, FMOC-ALA-PRO-OH, FMOC-GLY-GLY-GLY-OH, FMOC-GLY-PHE-OH, FMOC-GLY-PRO-OH, FMOC-GLY-VAL-OH, FOR-VAL-PHE-GLY-OH, H-LEU-LEU-GLY-OH, H-LYS-ARG-OH, H-MET-GLY-GLY-OH, H-MET-HIS-OH, H-PHE-ARG-OH HBR, H-PRO-VAL-GLY-OH, H-TRP-ASP-OH, H-TYR-GLY-GLY-OH, H-TYR-ILE-OH, H-TYR-LEU-OH, Z-ALA-ARG-OH, Z-ALA-ASP-OH, Z-GLU-LEU-OH, Z-GLU-VAL-OH.Z-GLY-GLU-OH, Z-GLY-GLY-TRP-OH, Z-GLY-GLY-TYR-OH, Z-HIS-ALA-OH, Z-HIS-TRP-OH, Z-ILE-SER-OH, Z-DL-LEU-DL-ALA-OH, Z-LEU-D-ALA-OH, Z-LEU-BETA-ALA-OH, Z-LEU-PHE-OH, Z-LEU-PRO-OH, Z-LEU-SER-OH, Z-PHE-PHE-OH, Z-PHE-TRP-OH, Z-PHE-VAL-OH, Z-PRO-BETA-ALA-OH, Z-SER-GLY-OH, Z-TRP-LEU-OH, Z-VAL-VAL-OH, AC-LYS(AC)-D-ALA-D-ALA-OH, AC-LYS(AC)-D-ALA-D-LYS-OH, AC-LYS(AC)-D-GLU-D-ALA-OH, H-D-GLU-D-GLU-OH, H-D-PHE-D-PHE-OH, H-D-VAL-D-VAL-D-VAL-D-VAL-OH, AC-HIS-GLY-HIS-OH, AC-HIS-PRO-PHE-OH, AC-HIS-SER-PHE-OH, AC-TYR-TYR-OH, BOC-GAMMA-GLU-LYS-OH, BOC-GLY-GLY-GLY-LYS-OH, BOC-PHE-GLY-GLY-GLY-OH, FMOC-ILE-PRO-OH, FMOC-NLE-NLE-OH, FMOC-PRO-PRO-OH, FMOC-VAL-PRO-OH, FOR-MET-LEU-GLU-OH, GLUTARYL-GLY-PHE-4M-BETA-NA, GLUTARYL-PHE-BETA-NA, H-ALA-ALA-ALA-ALA-D-GLU-OH, H-ALA-ALA-ALA-ALA-GLU-OH, H-ALA-ALA-ALA-TYR-ALA-OH, H-ALA-ALA-PRO-ALA-ALA-OH, H-ALA-ALA-TYR-ALA-OH, H-ARG-GLN-OH, H-ARG-GLY-GLY-OH, H-ARG-ILE-OH, H-ARG-PHE-ALA-OH, H-ARG-SER-ARG-OH, H-ASN-GLU-OH, H-ASP-ALA-HIS-LYS-OH, H-ASP-ALA-SER-GLY-GLU-OH, H-ASP-ASN-GLN-OH, H-ASP-TRP-OH, H-CIT-PHE-OH, H-D-ARG-PHE-OH, H-D-GLU-GLU-OH, H-D-PHE-SER(BZL)-PHE-OH, H-GAMMA-GLU-GAMMA-GLU-GLN-OH, H-GAMMA-GLU-GAMMA-GLU-GLU-OH, H-GAMMA-GLU-GAMMA-GLU-LYS-OH, H-GLN-TRP-GLU-OH, H-GLU-GLU-ASP-OH, H-GLU-GLU-BETA-NA, H-GLU-GLU-LEU-OH, H-GLU-HIS-GLY-OH, H-GLU-PHE-TYR-OH, H-GLU-PRO-GLU-THR-OH, H-GLU-SER-LEU-PHE-OH, H-GLY-GLY-ARG-ANILIDE, H-GLY-GLY-GLY-BETA-ALA-OH, H-GLY-GLY-LYS-ALA-ALA-OH, H-GLY-GLY-TYR-ALA-OH, H-GLY-LEU-BETA-ALA-OH, H-GLY-LEU-DELTA-AMINOVALERIC ACID, H-GLY-LEU-LEU-GLY-OH, H-GLY-LYS-GLY-OH, H-GLY-LYS-HIS-OH, H-HIS-TRP-LYS-OH, H-ILE-ARG-PRO-OH, H-ILE-GLN-OH, H-LEU-LEU-VAL-PHE-OH, H-LEU-PHE-LEU-OH, H-LYS-ALA-PHE-GLY-OH, H-LYS-ARG-OH, H-LYS-GLY-GLU-OH, H-LYS-GLY-GLY-LYS-OH, H-LYS-GLY-LYS-OH, H-LYS-LEU-LYS-OH, H-LYS-PHE-LYS-OH, H-LYS-PRO-ARG-OH, H-LYS-PRO-ASN-OH, H-LYS-SER-LYS-OH, H-LYS-TYR-THR-OH, H-MET-ASP-GLY-OH, H-MET-GLN-OH, H-MET-LEU-GLY-OH, H-MET-SER-GLY-OH, H-MET-TRP-GLY-OH, H-MET-TYR-LYS-OH, H-ORN-ORN-ORN-OH, H-PHE-ARG-ARG-OH, H-PHE-GLN-GLY-PRO-OH, H-PHE-TRP-NH2, H-PRO-GLU-THR-OH, H-PRO-HIS-GLU-OH, H-PRO-LEU-GLY-GLY-OH, H-PRO-PHE-LYS-OH, H-SER-GLU-GLY-OH, H-SER-TYR-LYS-OH, H-THR-TYR-LYS-OH, H-THR-TYR-SER-LYS-OH, H-TRP-ARG-OH , H-TRP-GLU-TYR-OH, H-TRP-GLY-GLY-TYR-OH, H-TRP-MET-OH, H-TRP-PRO-TYR-OH, H-TYR-ARG-PRO-NH2, H-TYR-ARG-THR-NH2, H-TYR-GLN-OH, H-TYR-GLU-TRP-OH, H-TYR-LYS-TRP-OH, H-TYR-TYR-LEU-NH2, H-TYR-TYR-LEU-OH, H-VAL-ARG-OH; L-BETA-PHENYLLACTYL-GLN-TYR-OH, L-BETA-PHENYLLACTYL-GLY-TYR-OH, L-BETA-PHENYLLACTYL-PHE-TYR-OH, Z-ALA-ALA-LYS-OH, Z-ALA-PRO-GLY-OH, Z-ALA-PRO-LEU-OH, Z-ASP-MET-OH, Z-D-ALA-PHE-OH, Z-D-GLU-TYR-OH, Z-DL-LEU-GLY-OH, Z-GLU-MET-OH, Z-GLY-ALA-ALA-OH, Z-GLY-GLN-OH, Z-GLY-GLY-GLY-GLY-GLY-GLY-OH, Z-GLY-GLY-HIS-OH, Z-GLY-ILE-ALA-OH, Z-GLY-LEU-ALA-OH, Z-GLY-LEU-GLY-OH, Z-GLY-PHE-ALA-OH, Z-GLY-PRO-ALA-OH, Z-GLY-PRO-GLY-GLY-OME, Z-HIS-MET-OH, Z-ILE-HIS-OH, Z-LYS(Z)-ALA-OH, Z-LYS(Z)-GLY-OH, Z-LYS-LEU-OH, Z-PHE-ASP-OH, Z-PHE-GLU-OH, Z-PHE-LEU-ALA-OH, Z-TRP-MET-OH, Z-TRP-VAL-OH, Z-TYR-ILE-OH, Z-VAL-GLY-PHE-OH, Z-VAL-TRP-OH, GLY-GLY-L-PHE-L-MET, L-TRP-TRP, L-TRP-TYR, Z-TYR-GLY-GLY-OH, H-MET-ASP-PHE-NH2, Z-GLY-ARG-OH, Z-ILE-GLU-OH, Z-LEU-D-PHE-OH, Z-PYR-HIS-OH, Z-LEU-GLU-OH, L-ARG-PHE-ALA, L-ARG-ARG, L-ASP-L-ARG, L-ALA-ALA-ALA-L-PRO-L-ALA-ALA, L-ALA-LEU-ALA-GLY, L-ARG-PRO-PRO, N-ACETYL-D-TRP-D-TRP, N-BENZOYL-L-ARG-PHE-ALA, CBZ-DL-PHE-GLY-GLY HYDRAZIDE, CBZ-L-ARG-PHE, CBZ-L-ALPHA-ASP-GLU, CBZ-GLY-GLY-L-ARG, CBZ-L-GLU-TRP, CBZ-D-ALA-L-ALA, CBZ-L-ALA-D-LEU, CBZ-D-LEU-L-ALA, CBZ-L-LEU-D-LEU, CBZ-L-VAL-D-LEU, CBZ-D-VAL-D-LEU, CBZ-L-VAL-D-PHE, GLY-ALA-ALA-D-ALA-L-ALA, ALPHA-L-GLU-L-TRP-L-GLU, GAMMA-L-GLU-GAMMA-L-GLU-L-ALA, L-LYS-L-TRP OH , L-LEU-TRP-MET , L-LEU-TRP-LEU, L-LYS-TYR-LYS, L-PHE-L-ARG, L-PRO-PHE-ARG, L-PHE-D-PHE, L-SER-GLY-ALA-GLY-ALA-GLY, L-TYR-L-MET, L-TRP-GLY-GLY-TYR, D-TRP-D-TRP, L-TYR-TYR, H-THR-ARG-OH, FMOC-PHE-GLY-OH, FMOC-D-CIS-HYP-OH, FMOC-D-ALLO-THR-OH, FMOC-ALLO-THR-OH, FMOC-D-ASP-OH, PYR-TRP-GLY-NH2, H-PHE-PRO-ARG-OH, BOC-GLY-GLY-GLY-GLY-OH, Z-PHE-GLY-OH, FMOC-ALA-ALA-PRO-OH, BOC-GLY-PRO-GLY-OH.

[0061] Examples of carrier-molecule-affinitive substances in the ligand compound according to the invention are selected from the following groups: [0062] naphthalene and naphthyl derivatives: for example [0063] 1,4,5,8-NAPHTHALENETETRACARBOXYLIC ACID, NAPHTHOL, [0064] 1,1?-(1,5-NAPHTHALENEDIYL)BIS(3-CYCLOHEXYLUREA), [0065] 4-ACETAMIDO-5-HYDROXY-2,7-NAPHTHALENE DISULFONIC ACID, [0066] 2-(2-HYDROXY-1-NAPHTHYLMETHYLENEAMINO)BENZOIC ACID, [0067] 9-FLUORENYLIDENEAMINO N-(1-NAPHTHYL)CARBAMATE, [0068] 2-(N-(1-NAPHTHYL)CARBAMOYL)CYCLOHEXANECARBOXYLIC ACID, [0069] 1,1?-(1,5-NAPHTHALENEDIYL)BIS(3-(3-PYRIDYLMETHYL)UREA), [0070] 1,1?-(1,5-NAPHTHALENEDIYL)BIS(3-BENZYLUREA), [0071] 2,2?-OXYBIS(ACETIC ACID (2-HYDROXY-1-NAPHTHYLMETHYLENE)HYDRAZIDE), [0072] ADIPIC ACID BIS((1-NAPHTHYLMETHYLENE)HYDRAZIDE), [0073] 3-(N-PHENYLCARBAMOYL)-2-NAPHTHYL N-(5-CHLORO-2-METHOXYPHENYL)CARBAMATE, [0074] 6-BENZOYL-2-NAPHTHYL PHOSPHATE, SODIUM SALT, [0075] L-ARGININE 4-METHOXY-BETA-NAPHTHYLAMIDE HYDROCHLORIDE, [0076] 1-AMINO-8-NAPHTHOL-2,4-DISULFONIC ACID, [0077] FMOC-D-2-NAPHTHYLALANINE, LYS-ALA 4-METHOXY-BETA-NAPHTHYLAMIDE DIHYDROCHLORIDE, [0078] 4-(1,8-DIHYDROXY-3,6-DISULFO-2-NAPHTHYLAZO)-SALICYLIC ACID, [0079] 1,1?-HEXAMETHYLENEBIS(3-(1-NAPHTHYLMETHYL)UREA, [0080] CARBOBENZYLOXYTRYPTOPHAN BETA-NAPHTHYLAMIDE, [0081] 3-(N-(2-METHOXYPHENYL)CARBAMOYL)-2-NAPHTHYL N-(5-CHLORO-2-METHOXYPHENYL)CARBAMATE, [0082] 2-(1-NAPHTHYL)-2-PHENYLACETIC ACID, 8-[(2-CARBOXYETHYL)THIO]-1-NAPHTHOIC ACID, [0083] 3-[1-(2-CARBOXYETHYL)-2-OXO-1,2-DIHYDROACENAPHTHYLEN-1-YL]PROPANOIC ACID, 3-[(1-NAPHTHYLAMINO)CARBONYL]BICYCLO[2.2.1]-HEPT-5-ENE-2-CARBOXYLIC ACID, [0084] N?,N??-DI[1-(2-NAPHTHYL)ETHYLIDENE]CARBONIC ACID DIHYDRAZIDE, [0085] 4-[[4-(2-NAPHTHYL)-1,3-THIAZOL-2-YL]AMINO]-4-OXOBUTANOIC ACID, [0086] FMOC-L-2-NAPHTHYLALANINE, 1,4,5,8-NAPHTHALENETETRACARBOXYLIC ACID HYDRATE, [0087] BIS(2-NAPHTHYL) N,N?-(4-METHYL-1,3-PHENYLENE)BISCARBAMATE, [0088] 8-HYDROXY-5-(1-NAPHTHYLAZO)-2-NAPHTHALENESULFONIC ACID, SODIUM SALT, [0089] N?1 ,N?3-DI(1-NAPHTHYLMETHYLIDENE)-2-BUTYLPROPANEDIOIC HYDRAZIDE, [0090] (+/?)-1,1?-BINAPHTHYL-2,2?-DICARBOXYLIC ACID, [0091] (+/?)-2,2?-DIMETHOXY-1,1?-BINAPHTHYL-3,3?-DICARBOXAMIDE, [0092] 1-HYDROXY-4-(1-PHENYL-1H-TETRAZOL-5-YL-THIO)-2-NAPHTHOIC ACID, 3,3?-DIPHENYL-(1,1)BINAPHTHALENYL-2,2?-DICARBOXYLIC ACID, [0093] 2,6-DIMETHOXY-4-OXO-3,5-DIOXA-PHOSPHA-CYCLOHEPTA(2,1-A,3,4-A?)DINAPHTHALEN-4-OL, [0094] 4-((BR-4-ME-PHENYLIMINO)-ME)-3-HO-NAPHTHALENE-2-CARBOXYLIC ACID (2-MEO-PH)AMIDE, [0095] 8-([2-[(METHYLAMINO)CARBONYL]PHENYL]THIO)-1-NAPHTHOIC ACID, [0096] N-GLUTARYL-L-PHENYLALANINE-BETA-NAPHTHYLAMIDE, [0097] 2-HYDROXY-3-NAPHTHOIC ACID 2-AMINOANTHRAQUIINONYLAMIDE PHOSPHATE, [0098] 2-HYDROXY-3-NAPHTHOIC ACID 2-AMINOAZOBENZANILIDE PHOSPHATE, [0099] 3-(5-(2-CARBOXYETHANESULFONYL)NAPHTHALENE-1-SULFONYL) PROPIONIC ACID, [0100] 4-((4-CL-PHENYLIMINO)-ME)-3-HO-NAPHTHALENE-2-CARBOXYLIC ACID (2-MEO-PH)-AMIDE, [0101] 4-HYDROXY-7-METHOXY-1-(3-METHOXY-PHENYL)-NAPHTHALENE-2-CARBOXYLIC ACID, [0102] 3,6-DISULFO-NAPHTHALENE-1,8-DICARBOXYLIC ACID, L-ALA-ALA-L-PHE-ALPHA-NAPHTHYLAMIDE, [0103] CBZ-L-TH R-L-VAL-BETA-NAPHTHYLAMIDE, CBZ-GLY-L-VAL-BETA-NAPHTHYLAMIDE, [0104] CBZ-ILE-L-ALA-BETA-NAPHTHYLAM IDE, CBZ-L-ALA-THR-BETA-NAPHTHYLAMIDE, [0105] DISODIUM 4-(BENZOYLAMINO)-5-METHYL-2,7-NAPHTHALENEDISULFONATE, [0106] NAPHTHALENE-1,4,8-TRICARBOXYLIC ACID, [0107] 2-[[2-(1-NAPHTHYL)ACETYL]AMINO]SUCCINIC ACID, [0108] (10-HO-10-PH-4H-8-THIA-7, 10A-DIAZA-PENTALENO(1,2-A)NAPHTHALEN-9-YL)ACETIC ACID, [0109] 1-(NAPHTHALENE-2-CARBONYL)-3-NAPHTHALEN-2-YLUREA, [0110] 1-(3-METHOXY-PHENYL)-3-(NAPHTHALENE-1-CARBONYL)THIOUREA, (S)—N—(1-(1-NAPHTHYL)ETHYL)SUCCINAMIC ACID, [0111] L-LYSYL-L-ALANINE-4-METHOXY-BETA-NAPHTHYLAMIDE HYDROBROMIDE, [0112] 5-((2-(T-BOC)-GAMMA-GLUTAMYLAMINOETHYL)AMINO)NAPHTHALENE-1-SULFONIC ACID, [0113] 8-([2-[(ACETYLOXY)METHYL]PHENYL]THIO)-1-NAPHTHOIC ACID, [0114] 2-[[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]AMINO]-3-(2-NAPHTHYL)PROPANOIC ACID, [0115] I-NAPHTHYLACETYLSPERMINE TRIHYDROCHLORIDE, [0116] 4-[(2-ETHOXY-2-OXOETHYL)THIO]NAPHTHALENE-1,8-DICARBOXYLIC ACID, FMOC-(R)-3-AMINO-4-(2-NAPHTHYL)BUTYRIC ACID, 2,2?-BIQUINONYL DICARBOXYLIC ACID; [0117] benzophenone derivatives: for example [0118] BENZOPHENONE 2,4?-DICARBOXYLIC ACID, [0119] 3,3?,4,4?-BENZOPHENONE TETRACARBOXYLIC ACID, [0120] 2?,3,4-BENZOPHENONE TRICARBOXYLIC ACID, [0121] 2,2?-DIHYDROXY-4,4?-DIMETHOXY-5-SULFOBENZOPHENONE, [0122] 4-[N-[2-(ACETAMIDO)ETHYL]-N-METHYLAMINO]-2?-CARBOXY-2-HYDROXYBENZOPHENONE; [0123] phthalimide and isophthalimide derivatives and phthalic acid and isophthalic acid derivatives: for example [0124] 5-SULFOISOPHTHALIC ACID MONOSODIUM SALT, [0125] 2-PHENYL-3-PHTHALIMIDOQUINOLINE-4-CARBOXYLIC ACID, [0126] 2-PHTHALIMIDOGLUTARIC ACID, [0127] 2,5-BIS(2-HYDROXYETHYLAMINO)TEREPHTHALIC ACID, [0128] 2- and/or 4-SULFOTEREPHTHALIC ACID, [0129] 5-SULFOISOPHTHALIC ACID, [0130] 2,5-BIS(N-(2,5-XYLYL)CARBAMOYL)TEREPHTHALIC ACID, [0131] 4-[(2-CARBOXYPHENYL)THIO]ISOPHTHALIC ACID, [0132] 4-(4-ACETYL-3-HYDROXY-2-PROPYLPHENOXY)ISOPHTHALIC ACID, 2,4,6-TRIMETHYLANILINE SALT, [0133] 4-(N-(4-METHOXYPHENYL)CARBAMOYL)ISOPHTHALIC ACID, [0134] PHTHALIC ACID MONO-((2-CHLOROPHENYL)PHENYLMETHYL) ESTER, [0135] 4-(4-(3,4-DIMETHYLPHENYLSULFANYL)BENZENESULFONYL)PHTHALIC ACID, [0136] 4-(4-(4-CARBOXYPHENOXY)-BENZOYL)PHTHALIC ACID, [0137] 4-(4-CHLORO-BENZOYL)PHTHALIC ACID, [0138] 5-(5-(4-HYDROXYPHENYL)-3-PHENYL-4,5-DIHYDROPYRAZOL-1-YL)ISOPHTHALIC ACID, [0139] 5-(5-(4-DIMETHYLAMINO-PH)-3-PHENYL-4,5-DIHYDRO-PYRAZOL-1-YL)ISOPHTHALIC ACID, [0140] PHTHALIC ACID MONO-(BIPHENYL-4-YL-PHENYLMETHYL) ESTER, PHTHALIC ACID.

Zu einzelnen im Rahmen des erfindungsgemäßen Verfahrens einsetzbaren monofunktionellen Bausteinen gehören u. a. (sowohl ?- als auch andere) wie Glycin, Alanin, Valin, Leucin, Isoleucin, Serin, Threonin, Asparaginsäure, Asparagin, Glutaminsäure, Glutamin, Prolin, Histidin, Tryptophan, Phenylalanin, Tyrosin, Methionin; lineare und verzweigte wie Ethylamin, Propylamin, Butylamin, sec.-Butylamin, tert.-Butylamin, Isobutylamin, Pentylamin, Isopentylamin, 2-Aminopentan, Hexylamin, Heptylamin, 2-Heptylamin, Octylamin, tert.-Octylamin, Nonylamin, Decylamin, Undecylamin, Dodecylamin, Ethanolamin, 3-Amino-1-propanol, 1-Amino-2-propanol, Alaninol, 2-Amino-1-butanol, 4-Amino-1-butanol, 2-Amino-2-methyl-1-propanol, 5-Amino-1-pentanol, Valinol, Leucinol, tert.-Leucinol, N-Propylethylendiamin, 2-Ethylamino-ethylamin; lineare und verzweigte , wie Ethanthiol, 1-Propanthiol, 2-Propanthiol, 1-Butanthiol, sec.-Butylmercaptan, tert.-Butylmercaptan, Isobutylmercaptan, 1-Pentanthiol, 1-Hexanthiol, 1-Heptanthiol, 1-Octanthiol, 1-Nonanthiol, 1-Decanthiol, 1-Undecanthiol, 1-Dodecanthiol, tert.-Dodecanthiol, 1-Tetradecanthiol, 1-Hexadecanthiol, 1-Octadecanthiol, Mercaptoethanol, 3-Mercapto-1-propanol, 4-Mercapto-1-butanol, 3-Mercapto-2-butanol, 6-Mercapto-1-hexanol, 8-Mercapto-1-octanol, 10-Mercapto-1-decanol, 11-Mercapto-1-undecanol, Mercaptoessigsäure und deren Salze und Ester, 3-Mercaptopropionsäure und deren Salze und Ester, 11-Mercaptoundecansäure und deren Salze und Ester, Mercaptoethansulfonsäure und deren Salze, 3-Mercapto-1-propansulfonsäure und deren Salze, Mercaptobrenztraubensäure und deren Salze, 2-Diethylaminoethanthiol(-hydrochlorid), 3-Mercaptopropylmethyldimethoxysilan, 3-Mercaptopropyl-triethoxysilan, 3-Mercaptopropyl-trimethoxysilan, N-Methylmercaptoacetamid, Mercaptophenol.

The individual monofunctional structural elements which can be used within the framework of the method of the invention include, among others, amino acids (both ?- and others) such as glycine, alanine, valine, leucine, isoleucine, serine, threonine, asparaginic acid, asparagine, glutamic acid, glutamine, proline, histidine, tryptophane, phenylalanine, tyrosine, methionine; linear and branched amines such as ethylamine, propylamine, butylamine, sec.-butylamine, tert.-butylamine, isobutylamine, pentylamine, isopentylamine, 2-aminopentane, hexylamine, heptylamine, 2-heptylamine, octylamine, tert.-octylamine, nonylamine, decylamine, undecylamine, dodecylamine, ethanolamine, 3-amino-1-propanol, 1-amino-2-propanol, alaninol, 2-amino-1-butanol, 4-amino-1-butanol, 2-amino-2-methyl-1-propanol, 5-amino-1-pentanol, valinol, leucinol, tert.-leucinol, N-propylethylene diamine, 2-ethylamino-ethylamine; linear and branched thiols such as ethanethiol, 1-propanethiol, 2-propanethiol, 1-butanethiol, sec.-butyl mercaptan, tert.-butyl mercaptan, isobutyl mercaptan, 1-pentanethiol, 1-hexanethiol, 1-heptanethiol, 1-octanethiol, 1-nonanethiol, 1-decanethiol, 1-undecanethiol, 1-dodecanethiol, tert.-dodecanethiol, 1-tetradecanethiol, 1-hexadecanethiol, 1-octadecanethiol, mercapto ethanol, 3-mercapto-1-propanol, 4-mercapto-1-butanol, 3-mercapto-2-butanol, 6-mercapto-1-hexanol, 8-mercapto-1-octanol, 10-mercapto-1-decanol, 11-mercapto-1-undecanol, mercaptoacetic acid and its salts and esters, 3-mercaptopropionic acid and its salts and esters, 11-mercaptoundecanoic acid and its salts and esters, mercaptoethane sulfonic acid and its salts, 3-mercapto-1-propane sulfonic acid and its salts, mercaptopyruvic acid and its salts, 2-diethylamino ethanethiol (-hydrochloride), 3-mercaptopropylmethyldimethoxysilane, 3-mercaptopropyltriethoxysilane, 3-mercaptopropyltrimethoxysilane, N-methylmercaptoacetamide, mercaptophenol.

Verbindung mit der Formel oder ein pharmazeutisch unbedenkliches Salz, Prodrug oder Ester davon, worin R Wasserstoff, Alkoxycarbonyl-, Aralkoxycarbonyl-, Alkylcarbonyl-, Cycloalkylcarbonyl-, Cycloalkylalkoxycarbonyl-, Cycloalkylalkanoyl-, Alkanoyl-, Aralkanoyl-, Aroyl-, Aryloxycarbonyl-, Aryloxycarbonylalkyl-, Aryloxyalkanoyl-, Heterocyclylcarbonyl-, Heterocyclyloxycarbonyl-, Heterocyclylalkanoyl-, Heterocyclylalkoxycarbonyl-, Heteroaralkanoyl-, Heteroaralkoxycarbonyl-, Heteroaryloxy-carbonyl-, Heteroaroyl-, Alkyl-, Alkenyl-, Alkinyl-, Cycloalkyl-, Aryl-, Aralkyl-, Aryloxyalkyl-, Heteroaryloxyalkyl-, Hydroxyalkyl-, Aminocarbonyl-, Aminoalkanoylund mono- und disubstituierte Aminocarbonyl- und mono- und disubstituierte Aminoalkanoylreste, worin die Substituenten ausgewählt sind aus Alkyl-, Aryl-, Aralkyl-, Cycloalkyl-, Cycloalkylalkyl-, Heteroaryl-, Heteroaralkyl-, Heterocycloalkyl-, Heterocycloalkylalkylresten oder, wo die Aminocarbonyl- und Aminoalkanoylreste disubstituiert sind, diese Substituenten zusammen mit dem Stickstoffatom, an das sie gebunden sind, einen Heterocycloalkyl- oder Heteroarylrest bilden, bedeutet; R' Wasserstoff oder Reste, wie sie für R definiert sind, oder R"SO -, worin R" Reste darstellt, wie sie für R definiert sind, bedeutet; oder R und R' zusammen mit dem Stickstoff, an den sie gebunden sind, einen Heterocycloalkyl- und Heteroarylrest darstellen; R Wasserstoff, -CH SO NH , -CH CO CH , -CO CH , -CONH , -CH C(O)NHCH , -C(CH ) (SH), -C(CH ) (SCH ), -C(CH ) (S[O]CH ), C(CH ) (S[O] CH ), Alkyl-, Halogenalkyl-, Alkenyl-, Alkinyl- und Cycloalkylreste und Aminosäureseitenketten ausgewählt aus Asparagin-, S-Methylcystein- und Sulfoxid(SO)- und Sulfon(SO )-Derivaten davon, Isoleucin-, Alloisoleucin-, Alanin-, Leucin-, tert-Leucin-, Phenylalanin-, Ornithin-, Histidin-, Norleucin-, Glutamin-, Threonin-, Glycin-, Allothreonin-, Serin-, O-Alkylserin-, Asparaginsäure-, beta-Cyanoalaninund Valinseitenketten bedeutet; R und R unabhängig Wasserstoff und Reste, wie sie für R definiert sind, bedeuten, oder eines von R und R zusammen mit R und den Kohlenstoffatomen, an die R , R und R gebunden sind, einen Cycloalkylrest darstellt; R Alkyl-, Aryl-, Cycloalkyl-, Cycloalkylalkyl- und Aralkylreste, welche Reste gegebenenfalls substituiert sind mit einer Gruppe ausgewählt aus Alkyl- und Halogenresten, -NO , -C?N, CF , -OR , -SR , worin R Wasserstoff und Alkylreste darstellt, bedeutet; R Wasserstoff, Alkyl-, Halogenalkyl-, Alkenyl-, Alkinyl-, Hydroxyalkyl-, Alkoxyalkyl-, Cycloalkyl-, Cycloalkylalkyl-, Heterocycloalkyl-, Heteroaryl-, Heterocycloalkylalkyl-, Aryl-, Aralkyl-, Heteroaralkyl-, Aminoalkyl- und mono- und disubstituierte Aminoalkylreste, worin die Substituenten ausgewählt sind aus Alkyl-, Aryl-, Aralkyl-, Cycloalkyl-, Cycloalkylalkyl-, Heteroaryl-, Heteroaralkyl-, Heterocycloalkyl- und Heterocycloalkylalkylresten, oder, im Falle eines disubstituierten Aminoalkylrestes, die Substituenten zusammen mit dem Stickstoffatom, an das sie gebunden sind, einen Heterocycloalkyl- oder einen Heteroarylrest bilden, bedeutet; R Reste darstellt, wie sie durch R definiert sind, mit Ausnahme von Wasserstoff; R Wasserstoff und Alkylreste darstellt; x für 0, 1 oder 2 steht; t für 0 oder 1 steht; und Y für O, S und NR steht, wobei R Wasserstoff und Reste, wie sie für R definiert sind, darstellt.

A compound represented by the formula: or a pharmaceutically acceptable salt, prodrug or ester thereof wherein: R represents hydrogen, alkoxycarbonyl, aralkoxycarbonyl, alkylcarbonyl, cycloalkylcarbonyl, cycloalkylalkoxycarbonyl, cycloalkylalkanoyl, alkanoyl, aralkanoyl, aroyl, aryloxycarbonyl, aryloxycarbonylalkyl, aryloxyalkanoyl, heterocyclylcarbonyl, heterocyclyloxycarbonyl, heterocyclylalkanoyl, heterocyclylalkoxycarbonyl, heteroaralkanoyl, heteroaralkoxycarbonyl, heteroaryloxy-carbonyl, heteroaroyl, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, aralkyl, aryloxyalkyl, heteroaryloxyalkyl, hydroxyalkyl, aminocarbonyl, aminoalkanoyl, and mono- and disubstituted aminocarbonyl and mono- and disubstituted aminoalkanoyl radicals wherein the substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, heterocycloalkyalkyl radicals, or wherein said aminocarbonyl and aminoalkanoyl radicals are disubstituted, said substituents along with the nitrogen atom to which they are attached form a heterocycloalkyl or heteroaryl radical; R' represents hydrogen and radicals as defined for R or R"SO - wherein R" represents radicals as defined for R ; or R and R' together with the nitrogen to which they are attached represent heterocycloalkyl and heteroaryl radical; R represents hydrogen, -CH SO NH , -CH CO CH , -CO CH , -CONH , -CH C(O)NHCH , -C(CH ) (SH), -C(CH ) (SCH ), -C(CH ) (S[O]CH ), -C(CH )2(S[O] CH ), alkyl, haloalkyl, alkenyl, alkynyl and cycloalkyl radicals, and amino acid side chains selected from asparagine, S-methyl cysteine and the sulfoxide (SO) and sulfone (SO ) derivatives thereof, isoleucine, allo-isoleucine, alanine, leucine, tert-leucine, phenylalanine, ornithine, histidine, norleucine, glutamine, threonine, glycine, allo-threonine, serine, O-alkyl serine, aspartic acid, beta-cyano alanine and valine side chains; R and R independently represent hydrogen and radicals as defined for R or one of R and R , together with R and the carbon atoms to which R , R and R are attached, represent a cycloalkyl radical; R represents alkyl, aryl, cycloalkyl, cycloalkylalkyl and aralkyl radicals, which radicals are optionally substituted with a group selected from alkyl and halogen radicals, -NO , -C?N, CF , -OR , -SR , wherein R represents hydrogen and alkyl radicals; R represents hydrogen, alkyl, haloalkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heteroaryl, heterocycloalkylalkyl, aryl, aralkyl, heteroaralkyl, aminoalkyl and mono- and disubstituted aminoalkyl radicals, wherein said substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, and heterocycloalkylalkyl radicals, or in the case of a disubstituted aminoalkyl radical, said substituents along with the nitrogen atom to which they are attached, form a heterocycloalkyl or a heteroaryl radical; R represents radicals as defined by R except for hydrogen; R represents hydrogen and alkyl radicals; x represents 0, 1, or 2; t represents either 0 or 1; and Y represents O, S and NR wherein R represents hydrogen and radicals as defined for R .